Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 3/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | HTR1D | P28221 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MASP2 | O00187 | 1/20 | 0.36 |
| ▸ | GAPDH | P04406 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.36 |
| ▸ | JUND | P17535 | 1/20 | 0.36 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20206922 | 1.00 | HTR5A (0.37) | HTR5AHTR1AHTR1DHTR2CHTR7 | |
| SCHEMBL21325331 | 0.80 | KDM4E (0.35) | HTR5AHTR1AHTR1DHTR2CHTR7 | |
| SCHEMBL21324838 | 0.80 | HTR2B (0.37) | HTR5AHTR1AHTR1DHTR2CHTR7 | |
| SCHEMBL19068822 | 0.74 | BRD4 (0.33) | — | |
| SCHEMBL20341633 | 0.73 | BRD4 (0.33) | — | |
| SCHEMBL20206729 | 0.70 | CTNNB1 (0.40) | HTR5AALDH1A1HSD17B10MAPT | |
| SCHEMBL14483912 | 0.69 | DRD2 (0.46) | HTR5AHTR1AACHE | |
| SCHEMBL13998649 | 0.69 | ADRA1D (0.50) | HTR1AHTR7KDM4EALDH1A1HPGD | |
| SCHEMBL517074 | 0.68 | BRD4 (0.54) | HTR1AHPGD | |
| SCHEMBL19392968 | 0.68 | BRD4 (0.54) | HTR1AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018098204-A1 | 6-MEMBERED URACIL ISOSTERES | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |