Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.32 |
| ▸ | GHSR | Q92847 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 2/20 | 0.30 |
| ▸ | MMP9 | P14780 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23558823 | 0.78 | ALDH1A1 (0.42) | PARP10PARP3ALDH1A1CYP2A6KDM4E | |
| SCHEMBL20187352 | 0.74 | KMT2A (0.39) | PARP10PARP3ALDH1A1CYP2A6KDM4E | |
| SCHEMBL24512557 | 0.67 | PARP10 (0.41) | PARP10PARP3ALDH1A1CYP2A6KDM4E | |
| SCHEMBL8546955 | 0.66 | ALDH1A1 (0.55) | PARP10PARP3ALDH1A1CYP2A6KDM4E | |
| SCHEMBL1663469 | 0.65 | PARP10 (0.65) | PARP10PARP3ALDH1A1CYP2A6KDM4E | |
| SCHEMBL5050902 | 0.65 | PARP10 (0.65) | PARP10PARP3ALDH1A1CYP2A6KDM4E | |
| SCHEMBL23558770 | 0.64 | TSHR (0.39) | ALDH1A1SMN1; SMN2KMT2A | |
| Fluoromethane SCHEMBL28219755 | 0.64 | ALDH1A1 (0.62) | PARP10PARP3ALDH1A1CYP2A6KDM4E | |
| SCHEMBL920261 | 0.64 | ALDH1A1 (0.66) | PARP10PARP3ALDH1A1KDM4ELMNA | |
| SCHEMBL6853633 | 0.63 | SRC (0.53) | PARP10PARP3ALDH1A1CYP2A6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10316021-B2 | Heteroarylphenoxy benzamide kappa opioid ligands | PFIZER INC. (US) | 2019-06-11 | — | — | US | disclosed |
| US-20180148432-A1 | HETEROARYLPHENOXY BENZAMIDE KAPPA OPIOID LIGANDS | PFIZER INC. (US) | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10316021-B2 | Heteroarylphenoxy benzamide kappa opioid ligands | OPRK1, OPRD1, OPRM1 | PARP10 1704/4885PARP3 2239/4885ALDH1A1 1595/4885 |
| US-20180148432-A1 | HETEROARYLPHENOXY BENZAMIDE KAPPA OPIOID LIGANDS | OPRK1, OPRD1, OPRM1 | PARP10 1704/4885PARP3 2239/4885ALDH1A1 1595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.