Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | CETP | P11597 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | THPO | P40225 | 2/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22240387 | 0.85 | LMNA (0.51) | LMNAKMT2ACETPALDH1A1SMN1; SMN2 | |
| SCHEMBL24251989 | 0.85 | LMNA (0.47) | LMNAKMT2AHDAC6CETPALDH1A1 | |
| Melphalan Flufenamide SCHEMBL20208719 | 0.84 | LMNA (0.53) | LMNAKMT2ACETPALDH1A1SMN1; SMN2 | |
| Melphalan Flufenamide SCHEMBL24101233 | 0.84 | LMNA (0.53) | LMNAKMT2ACETPALDH1A1SMN1; SMN2 | |
| Melphalan Flufenamide SCHEMBL18239898 | 0.84 | LMNA (0.53) | LMNAKMT2ACETPALDH1A1SMN1; SMN2 | |
| SCHEMBL30915227 | 0.84 | ALDH1A1 (0.48) | LMNAKMT2AHDAC6ALDH1A1SMN1; SMN2 | |
| SCHEMBL29227595 | 0.84 | ALDH1A1 (0.48) | LMNAKMT2AHDAC6ALDH1A1SMN1; SMN2 | |
| Melphalan Flufenamide SCHEMBL29375249 | 0.83 | LMNA (0.52) | LMNAKMT2ACETPALDH1A1SMN1; SMN2 | |
| SCHEMBL24506990 | 0.80 | LMNA (0.46) | LMNAKMT2ACETPALDH1A1SMN1; SMN2 | |
| SCHEMBL18239928 | 0.80 | CTSS (0.53) | LMNAKMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10287316-B2 | Process for preparation of nitrogen mustard derivatives | ONCOPEPTIDES AB (SE) | 2019-05-14 | — | — | US | disclosed |
| US-20180148473-A1 | PROCESS FOR PREPARATION OF NITROGEN MUSTARD DERIVATIVES | ONCOPEPTIDES AB (SE) | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180148473-A1 | PROCESS FOR PREPARATION OF NITROGEN MUSTARD DERIVATIVES | CBR3, GRHPR, CTH | LMNA 2888/4885KMT2A 2094/4885HDAC6 3055/4885 |
| US-10287316-B2 | Process for preparation of nitrogen mustard derivatives | CBR3, GRHPR, CTH | LMNA 2888/4885KMT2A 2094/4885HDAC6 3055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.