Sugi Predict

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SCHEMBL20209151

SCHEMBL20209151

COc1ccc2c(-c3ccc(Cl)cc3F)c(OC)ccc2c1-c1ccc(Cl)cc1F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.40
▸ GAA P10253 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ FLT1 P17948 2/20 0.39
▸ EGFR P00533 1/20 0.39
▸ FGFR1 P11362 1/20 0.39
▸ EPHB2 P29323 1/20 0.39
▸ FLT4 P35916 1/20 0.39
▸ KDR P35968 1/20 0.39
▸ PTGS2 P35354 2/20 0.39
▸ ALDH1A1 P00352 2/20 0.39
▸ HIF1A Q16665 1/20 0.39
▸ EPAS1 Q99814 1/20 0.39
▸ AMY1A P0DUB6 1/20 0.38
▸ KDM4E B2RXH2 2/20 0.38
▸ S1PR4 O95977 1/20 0.38
▸ HSP90AA1 P07900 1/20 0.38
▸ MAPT P10636 1/20 0.38
▸ G6PD P11413 1/20 0.38
▸ S1PR1 P21453 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL34467644 0.85 MAPT (0.57) LMNAGAAKMT2AALDH1A1MAPT
SCHEMBL21108850 0.85 TGFBR1 (0.42) LMNAGAAKMT2APTGS2AMY1A
SCHEMBL28524194 0.84 AMY1A (0.46) KMT2AKDRAMY1AKDM4EMAPT
SCHEMBL21450434 0.81 AMY1A (0.39) LMNAGAAKMT2APTGS2ALDH1A1
SCHEMBL24722210 0.80 HSP90AA1 (0.39) LMNAGAAKMT2AFLT1EGFR
SCHEMBL22737966 0.79 HSP90AA1 (0.46) LMNAGAAKMT2AFLT1EGFR
SCHEMBL20209464 0.79 HSP90AA1 (0.43) LMNAGAAKMT2AFLT1EGFR
SCHEMBL1765256 0.78 LMNA (0.50) LMNAGAAKMT2AFLT1EGFR
SCHEMBL1023561 0.76 LMNA (0.48) LMNAGAAKMT2AFLT1EGFR
SCHEMBL22375222 0.75 HSP90AA1 (0.46) LMNAGAAKMT2AFLT1EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12004419-B2 Electroactive compounds LG CHEM, LTD. (KR) 2024-06-04 — — US disclosed
CN-114940681-A Electroactive compounds 株式会社LG化学 2022-08-26 — — CN disclosed
CN-110023319-B Electroactive compounds 株式会社LG化学 2022-06-17 — — CN disclosed
US-20220093872-A1 Electroactive Compounds LG CHEM, LTD. (KR) 2022-03-24 — — US disclosed
US-11239426-B2 Electroactive compounds LG CHEM, LTD. 2022-02-01 — — US disclosed
US-11239426-B2 Electroactive compounds LG CHEM, LTD. 2022-02-01 — — US disclosed
WO-2018097937-A1 ELECTROACTIVE COMPOUNDS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2018-05-31 — — WO disclosed
WO-2018097937-A1 ELECTROACTIVE COMPOUNDS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2018-05-31 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220093872-A1 Electroactive Compounds KCNN3, KCNN2, HCN3 LMNA 2804/4885GAA 2066/4885KMT2A 3397/4885
US-12004419-B2 Electroactive compounds KCNN3, KCNN2, HCN3 LMNA 2804/4885GAA 2066/4885KMT2A 3397/4885
US-11239426-B2 Electroactive compounds KCNN2, HCN2, KCNN3 LMNA 2952/4885GAA 1937/4885KMT2A 3000/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.