Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.40 |
| ▸ | MAOB | P27338 | 4/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | DRD1 | P21728 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5437532 | 0.89 | DRD2 (0.39) | MAOAMAOBSLC6A4CYP2D6DRD2 | |
| SCHEMBL29557955 | 0.86 | MAOA (0.40) | MAOAMAOBSLC6A4DRD2DRD1 | |
| SCHEMBL24040089 | 0.86 | MAOA (0.40) | MAOAMAOBSLC6A4DRD2DRD1 | |
| SCHEMBL29310333 | 0.81 | MAOA (0.41) | MAOAMAOBSLC6A4CYP1A2CYP2D6 | |
| SCHEMBL29310310 | 0.79 | KDM4E (0.42) | MAOAMAOBSLC6A4CYP1A2CYP2D6 | |
| SCHEMBL25302605 | 0.79 | MAOA (0.40) | MAOAMAOBSLC6A4CYP1A2CYP2D6 | |
| SCHEMBL6791190 | 0.76 | ADRA2A (0.37) | MAOAMAOBSLC6A4DRD2DRD1 | |
| SCHEMBL20214597 | 0.73 | L3MBTL1 (0.44) | MAPT | |
| SCHEMBL24688300 | 0.73 | ADRA2C (0.38) | MAOAMAOBSLC6A4CYP2D6DRD2 | |
| SCHEMBL24773419 | 0.72 | MAOA (0.40) | MAOAMAOBSLC6A4DRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3548479-A1 | ANILINOPYRIMIDINES AS HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) INHIBITORS | ARIAD Pharmaceuticals, Inc. (US) | 2019-10-09 | — | — | EP | disclosed |
| WO-2018102366-A1 | ANILINOPYRIMIDINES AS HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2018-06-07 | — | — | WO | disclosed |