Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 9/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20215265 | 0.93 | ALDH1A1 (0.40) | P2RX7RXFP1POLBMAPTLMNA | |
| SCHEMBL20215246 | 0.93 | PPARG (0.37) | P2RX7RXFP1POLBNOTUMALDH1A1 | |
| SCHEMBL20215256 | 0.92 | KDM4E (0.43) | P2RX7POLBMAPTLMNATP53 | |
| SCHEMBL20215244 | 0.92 | MAPT (0.39) | P2RX7POLBMAPTLMNATP53 | |
| SCHEMBL20215230 | 0.91 | MAPK14 (0.43) | P2RX7POLBMAPTNOTUMMAPK14 | |
| SCHEMBL20215253 | 0.91 | MAPT (0.49) | P2RX7RXFP1MAPTLMNATP53 | |
| SCHEMBL20215239 | 0.91 | P2RX7 (0.38) | P2RX7RXFP1MAPTLMNATP53 | |
| SCHEMBL20215257 | 0.91 | CHRM5 (0.46) | P2RX7MAPTNOTUMDPP8ALDH1A1 | |
| SCHEMBL20215217 | 0.91 | P2RX7 (0.43) | P2RX7MAPTLMNANOTUMALDH1A1 | |
| SCHEMBL20215274 | 0.90 | CHRM5 (0.40) | P2RX7RXFP1POLBMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9988373-B2 | Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same | SHIONOGI & CO., LTD. (JP) | 2018-06-05 | — | — | US | disclosed |
| US-9988373-B2 | Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same | SHIONOGI & CO., LTD. (JP) | 2018-06-05 | — | — | US | disclosed |