Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.38 |
| ▸ | FNTA | P49354 | 3/20 | 0.38 |
| ▸ | FNTB | P49356 | 3/20 | 0.38 |
| ▸ | PGGT1B | P53609 | 3/20 | 0.38 |
| ▸ | MGLL | Q99685 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20215274 | 0.94 | CHRM5 (0.40) | P2RX7MEN1KMT2ANR1H2NR1H3 | |
| SCHEMBL20215219 | 0.91 | P2RX7 (0.41) | P2RX7MAPK14ALDH1A1LMNATP53 | |
| SCHEMBL20215234 | 0.89 | CHRM5 (0.40) | P2RX7LMNATP53MAPT | |
| SCHEMBL20215260 | 0.89 | MAPT (0.48) | P2RX7MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL20215265 | 0.87 | ALDH1A1 (0.40) | P2RX7MAPK14ALDH1A1NR1H2NR1H3 | |
| SCHEMBL20215256 | 0.85 | KDM4E (0.43) | P2RX7MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL20215267 | 0.85 | MAPK14 (0.46) | P2RX7MAPK14 | |
| SCHEMBL20215254 | 0.85 | HCRTR1 (0.41) | P2RX7KMT2AMAPT | |
| SCHEMBL20215230 | 0.84 | MAPK14 (0.43) | P2RX7MEN1KMT2AMAPK14KDM4E | |
| SCHEMBL20215246 | 0.84 | PPARG (0.37) | P2RX7KDM4EALDH1A1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9988373-B2 | Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same | SHIONOGI & CO., LTD. (JP) | 2018-06-05 | — | — | US | disclosed |
| US-9988373-B2 | Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same | SHIONOGI & CO., LTD. (JP) | 2018-06-05 | — | — | US | disclosed |