Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.41 |
| ▸ | DBH | P09172 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.37 |
| ▸ | UBE2N | P61088 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20215217 | 0.91 | P2RX7 (0.43) | THRBALDH1A1SMN1; SMN2MAPTP2RX7 | |
| SCHEMBL20215219 | 0.91 | P2RX7 (0.41) | MAPK14POLBALDH1A1MAPTP2RX7 | |
| SCHEMBL20215256 | 0.90 | KDM4E (0.43) | POLBTHRBDBHKDM4EMEN1 | |
| SCHEMBL20215253 | 0.89 | MAPT (0.49) | KDM4EALDH1A1KMT2ASMN1; SMN2CA12 | |
| SCHEMBL20215238 | 0.88 | S1PR1 (0.36) | POLBEPHX2KDM4EALDH1A1MAPT | |
| SCHEMBL20215231 | 0.88 | MAPT (0.46) | POLBKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL20215244 | 0.87 | MAPT (0.39) | POLBTHRBKDM4EALDH1A1MAPT | |
| SCHEMBL20215265 | 0.87 | ALDH1A1 (0.40) | MAPK14POLBALDH1A1MAPTP2RX7 | |
| SCHEMBL20215257 | 0.86 | CHRM5 (0.46) | KDM4EALDH1A1SMN1; SMN2CA12CA9 | |
| SCHEMBL20215232 | 0.85 | MAPT (0.47) | POLBTHRBKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9988373-B2 | Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same | SHIONOGI & CO., LTD. (JP) | 2018-06-05 | — | — | US | disclosed |
| US-9988373-B2 | Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same | SHIONOGI & CO., LTD. (JP) | 2018-06-05 | — | — | US | disclosed |