Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 8/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20215231 | 0.91 | MAPT (0.46) | MAPTTP53P2RX7MEN1KMT2A | |
| SCHEMBL20215244 | 0.91 | MAPT (0.39) | MAPTTP53P2RX7KCNH2KDM4E | |
| SCHEMBL20215257 | 0.90 | CHRM5 (0.46) | MAPTP2RX7KDM4ENOTUM | |
| SCHEMBL20215217 | 0.90 | P2RX7 (0.43) | MAPTP2RX7LMNATHRBNOTUM | |
| SCHEMBL20215219 | 0.90 | P2RX7 (0.41) | MAPTTP53P2RX7POLBLMNA | |
| SCHEMBL20215242 | 0.88 | MAPT (0.46) | MAPTTP53P2RX7KDM4ELMNA | |
| SCHEMBL20215246 | 0.88 | PPARG (0.37) | P2RX7KDM4EPOLBNOTUM | |
| SCHEMBL20215264 | 0.87 | P2RX7 (0.43) | MAPTP2RX7NOTUM | |
| SCHEMBL20215256 | 0.86 | KDM4E (0.43) | MAPTTP53P2RX7MEN1KMT2A | |
| SCHEMBL20215227 | 0.86 | CYP11B1 (0.39) | KDM4EPOLBNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9988373-B2 | Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same | SHIONOGI & CO., LTD. (JP) | 2018-06-05 | — | — | US | disclosed |
| US-9988373-B2 | Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same | SHIONOGI & CO., LTD. (JP) | 2018-06-05 | — | — | US | disclosed |