Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20215232 | 0.91 | MAPT (0.47) | MAPTTP53POLBMEN1KMT2A | |
| SCHEMBL20215219 | 0.90 | P2RX7 (0.41) | MAPTTP53POLBLMNAALDH1A1 | |
| SCHEMBL20215256 | 0.89 | KDM4E (0.43) | MAPTTP53POLBMEN1KMT2A | |
| SCHEMBL20215253 | 0.88 | MAPT (0.49) | MAPTTP53KMT2AKDM4ELMNA | |
| SCHEMBL20215230 | 0.88 | MAPK14 (0.43) | MAPTPOLBMEN1KMT2AKDM4E | |
| SCHEMBL20215238 | 0.87 | S1PR1 (0.36) | MAPTTP53POLBKDM4ELMNA | |
| SCHEMBL20215244 | 0.86 | MAPT (0.39) | MAPTTP53POLBKDM4ELMNA | |
| SCHEMBL20215260 | 0.86 | MAPT (0.48) | MAPTTP53POLBMEN1KMT2A | |
| SCHEMBL20215265 | 0.86 | ALDH1A1 (0.40) | MAPTTP53POLBLMNAALDH1A1 | |
| SCHEMBL20215257 | 0.85 | CHRM5 (0.46) | MAPTKDM4EALDH1A1P2RX7CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9988373-B2 | Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same | SHIONOGI & CO., LTD. (JP) | 2018-06-05 | — | — | US | disclosed |
| US-9988373-B2 | Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same | SHIONOGI & CO., LTD. (JP) | 2018-06-05 | — | — | US | disclosed |