Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.44 |
| ▸ | LPO | P22079 | 3/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20215242 | 0.92 | MAPT (0.46) | MAPTTP53LMNAP2RX7CMA1 | |
| SCHEMBL20215234 | 0.90 | CHRM5 (0.40) | MAPTTP53LMNAP2RX7CHRM5 | |
| SCHEMBL20215239 | 0.89 | P2RX7 (0.38) | MAPTTP53LMNAMEN1KMT2A | |
| SCHEMBL20215219 | 0.87 | P2RX7 (0.41) | MAPTTP53LMNAP2RX7ALDH1A1 | |
| SCHEMBL20215231 | 0.86 | MAPT (0.46) | MAPTTP53LMNAMEN1KMT2A | |
| SCHEMBL20215256 | 0.86 | KDM4E (0.43) | MAPTTP53LMNAMEN1KMT2A | |
| SCHEMBL20215230 | 0.85 | MAPK14 (0.43) | MAPTMEN1KMT2AP2RX7AR | |
| SCHEMBL20215253 | 0.85 | MAPT (0.49) | MAPTTP53LMNAKMT2AP2RX7 | |
| SCHEMBL20215274 | 0.84 | CHRM5 (0.40) | MAPTTP53LMNAMEN1KMT2A | |
| SCHEMBL20215238 | 0.84 | S1PR1 (0.36) | MAPTTP53LMNAP2RX7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9988373-B2 | Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same | SHIONOGI & CO., LTD. (JP) | 2018-06-05 | — | — | US | disclosed |
| US-9988373-B2 | Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same | SHIONOGI & CO., LTD. (JP) | 2018-06-05 | — | — | US | disclosed |