Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 3/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.38 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
| ▸ | F3 | P13726 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 4/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 3/20 | 0.37 |
| ▸ | PLG | P00747 | 2/20 | 0.37 |
| ▸ | PLAT | P00750 | 2/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217530 | 0.91 | KDR (0.40) | KDRF2PRSS1F10PRSS2 | |
| SCHEMBL20217431 | 0.86 | KDR (0.41) | KDRF2PRSS1F10PRSS2 | |
| SCHEMBL20217430 | 0.81 | F10 (0.42) | KDRF2PRSS1F10PRSS2 | |
| SCHEMBL20217286 | 0.81 | CYP3A4 (0.41) | KDRF2PRSS1F10PRSS2 | |
| SCHEMBL20217215 | 0.80 | HTR1E (0.43) | KMT2AMEN1LMNAHTR1EHTT | |
| SCHEMBL20217405 | 0.78 | MAPT (0.44) | KDRF10PDE4APDE4BPDE4C | |
| SCHEMBL14873449 | 0.77 | DYRK1A (0.49) | NAMPTCLK2CLK3DYRK1A | |
| SCHEMBL20217594 | 0.76 | F10 (0.43) | KDRF2PRSS1F10PRSS2 | |
| SCHEMBL20217257 | 0.76 | F10 (0.41) | KDRF2PRSS1F10PRSS2 | |
| SCHEMBL20217239 | 0.76 | F10 (0.41) | KDRF2PRSS1F10PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |