Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.40 |
| ▸ | CLK2 | P49760 | 2/20 | 0.40 |
| ▸ | CLK3 | P49761 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 8/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
| ▸ | F3 | P13726 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217530 | 0.86 | KDR (0.40) | KDRDYRK1ACLK2CLK3GSK3B | |
| SCHEMBL20217416 | 0.86 | KDR (0.41) | KDRDYRK1ACLK2CLK3F10 | |
| SCHEMBL20217632 | 0.84 | CYP3A4 (0.52) | KDRCYP3A4TTKAURKBINCENP | |
| SCHEMBL20217315 | 0.83 | CYP3A4 (0.52) | KDRCYP3A4TTKAURKBINCENP | |
| SCHEMBL20217450 | 0.81 | CYP3A4 (0.42) | KDRROCK2CYP3A4TTKAURKB | |
| SCHEMBL20217751 | 0.81 | CYP3A4 (0.55) | KDRCYP3A4TTKAURKBINCENP | |
| SCHEMBL20217430 | 0.81 | F10 (0.42) | KDRDYRK1ACLK2CLK3F10 | |
| SCHEMBL20217418 | 0.80 | FFAR2 (0.45) | KDRGRM4LMNAMEN1HTR1E | |
| SCHEMBL15477042 | 0.79 | CYP3A4 (0.55) | DYRK1ACLK2CLK3ROCK2CYP3A4 | |
| SCHEMBL20217405 | 0.77 | MAPT (0.44) | KDRROCK2F10LCKLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |