Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 5/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | F7 | P08709 | 1/20 | 0.42 |
| ▸ | F3 | P13726 | 1/20 | 0.42 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 3/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217530 | 0.81 | KDR (0.40) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL20217416 | 0.81 | KDR (0.41) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL20217431 | 0.81 | KDR (0.41) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL20217405 | 0.80 | MAPT (0.44) | F10KDRLMNA | |
| SCHEMBL20217221 | 0.79 | TTK (0.51) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL20217257 | 0.79 | F10 (0.41) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL20217239 | 0.78 | F10 (0.41) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL20217290 | 0.77 | ALDH1A1 (0.49) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL20217833 | 0.77 | HRH1 (0.42) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL20217340 | 0.76 | MEN1 (0.42) | F10PRSS1PRSS2PRSS3F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |