Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217515 | 0.88 | ALDH1A1 (0.39) | HPGDMEN1KMT2ALMNAPOLB | |
| SCHEMBL20217804 | 0.84 | RAB9A (0.43) | KDM4ERAB9ANPC1L3MBTL1MEN1 | |
| SCHEMBL20217956 | 0.83 | CYP3A4 (0.48) | CYP3A4 | |
| SCHEMBL20217375 | 0.80 | — | — | |
| SCHEMBL20217630 | 0.78 | RAB9A (0.45) | KDM4EHPGDHSD17B10RAB9ANPC1 | |
| SCHEMBL20217438 | 0.77 | KDM4E (0.50) | KDM4EHPGDHSD17B10RAB9ANPC1 | |
| SCHEMBL20217662 | 0.77 | CYP3A4 (0.47) | MEN1KMT2ACYP3A4ALDH1A1MAPK1 | |
| SCHEMBL20217514 | 0.77 | — | — | |
| SCHEMBL20217341 | 0.75 | CYP3A4 (0.40) | HPGDRAB9ANPC1LMNACYP3A4 | |
| SCHEMBL20217432 | 0.75 | KMT2A (0.47) | KDM4EHPGDHSD17B10RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |