Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217165 | 0.83 | KDM4E (0.58) | KDM4EHPGDHSD17B10MEN1KMT2A | |
| SCHEMBL14393413 | 0.83 | HPGD (0.69) | KDM4EHPGDHSD17B10MEN1KMT2A | |
| SCHEMBL20217538 | 0.81 | KMT2A (0.44) | KDM4EHPGDHSD17B10MEN1KMT2A | |
| SCHEMBL20217652 | 0.78 | TAS1R3 (0.40) | KMT2ALMNARAB9ANPC1POLB | |
| SCHEMBL20217247 | 0.78 | KMT2A (0.48) | KDM4EHPGDHSD17B10MEN1KMT2A | |
| SCHEMBL20217423 | 0.77 | KDM4E (0.40) | KDM4EHPGDHSD17B10MEN1KMT2A | |
| SCHEMBL20217432 | 0.77 | KMT2A (0.47) | KDM4EHPGDHSD17B10MEN1KMT2A | |
| SCHEMBL20217630 | 0.77 | RAB9A (0.45) | KDM4EHPGDHSD17B10MEN1KMT2A | |
| SCHEMBL20217804 | 0.77 | RAB9A (0.43) | KDM4EMEN1KMT2ALMNARAB9A | |
| SCHEMBL20217401 | 0.77 | KDM4E (0.44) | KDM4EMEN1KMT2ALMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |