Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 1/20 | 0.40 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RNF4 | P78317 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2026353 | 0.85 | TUBB4A (0.36) | ZAP70KARS1GAATRPM8MAPT | |
| SCHEMBL2021495 | 0.82 | ZAP70 (0.40) | ZAP70KARS1MAPK1TP53SMN1; SMN2 | |
| SCHEMBL12638340 | 0.81 | ZAP70 (0.39) | ZAP70KARS1MAPK1RNF4MAPT | |
| SCHEMBL12574759 | 0.81 | NPC1 (0.38) | ZAP70KARS1MAPK1RNF4SMN1; SMN2 | |
| SCHEMBL12476187 | 0.81 | TSHR (0.39) | ZAP70KARS1MAPK1RNF4CYP1A2 | |
| SCHEMBL2020203 | 0.80 | ZAP70 (0.33) | ZAP70KARS1SMN1; SMN2GAAMAPT | |
| SCHEMBL2023131 | 0.79 | CYP1A2 (0.41) | TP53SMN1; SMN2CYP1A2ALDH1A1KMT2A | |
| SCHEMBL12575032 | 0.79 | ZAP70 (0.36) | ZAP70KARS1MAPK1RNF4TP53 | |
| SCHEMBL2026164 | 0.77 | LMNA (0.36) | ZAP70KARS1MAPK1TP53SMN1; SMN2 | |
| SCHEMBL2025118 | 0.76 | RAB9A (0.46) | ZAP70KARS1MAPK1TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110160215-A1 | Substituted Triazolo-Pyrazine Compounds | ARQULE, INC. (US) | 2011-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160215-A1 | Substituted Triazolo-Pyrazine Compounds | MKI67, TP53, THPO | ZAP70 687/4885KARS1 1193/4885MAPK1 2007/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.