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SCHEMBL2021936

SCHEMBL2021936

CC(C)(C)OC(=O)N(OC(=O)N1CCC(N2CCCCC2)CC1)S(=O)(=O)c1ccccc1S(C)(=O)=O

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 7/20 0.41
▸ L3MBTL3 Q96JM7 6/20 0.40
▸ L3MBTL1 Q9Y468 5/20 0.40
▸ TP53BP1 Q12888 2/20 0.40
▸ STS P08842 1/20 0.40
▸ OPRM1 P35372 1/20 0.40
▸ OPRD1 P41143 1/20 0.40
▸ OGFRL1 Q5TC84 1/20 0.40
▸ HRH3 Q9Y5N1 1/20 0.39
▸ ACHE P22303 1/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ MBTD1 Q05BQ5 4/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2024375 0.90 GPR119 (0.42) GPR119L3MBTL3L3MBTL1STSACHE
SCHEMBL12546547 0.85 GPR119 (0.45) GPR119STS
SCHEMBL1925858 0.85 STS (0.45) GPR119STS
SCHEMBL1926954 0.83 GPR119 (0.39) GPR119STS
SCHEMBL1925298 0.83 MAPK1 (0.38) GPR119STS
SCHEMBL1949117 0.83 SMN1; SMN2 (0.45) GPR119STSMEN1KMT2A
SCHEMBL1926180 0.78 GPR119 (0.43) GPR119MEN1KMT2A
SCHEMBL2028194 0.77 MAPK1 (0.44) GPR119L3MBTL1STSHRH3MEN1
SCHEMBL1925711 0.76 ATM (0.38) GPR119L3MBTL1MEN1KMT2A
SCHEMBL2026566 0.76 GAA (0.38) GPR119STS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2509941-B1 N-ACYLATED HYDROXYLAMINE DERIVATIVES AND O-ACYLATED HYDROXYLAMINE DERIVATIVES UNIV JOHNS HOPKINS (US) 2019-01-23 — — EP disclosed
US-20180050985-A1 N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES THE JOHNS HOPKINS UNIVERSITY 2018-02-22 — — US disclosed
US-20160046570-A1 N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES THE JOHNS HOPKINS UNIVERSITY 2016-02-18 — — US disclosed
US-20140235636-A1 N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES CARDIOXYL PHARMACEUTICALS, INC. (US) 2014-08-21 — — US disclosed
US-20110144067-A1 N-Acyloxysulfonamide and N-Hydroxy-N-Acylsulfonamide Derivatives THE JOHNS HOPKINS UNIVERSITY 2011-06-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140235636-A1 N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES TNNI3, TNNT2, TNNC1 GPR119 804/4885L3MBTL3 2317/4885L3MBTL1 2461/4885
US-20180050985-A1 N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES TNNI3, TNNT2, NOS2 GPR119 800/4885L3MBTL3 2294/4885L3MBTL1 2494/4885
US-20160046570-A1 N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES TNNI3, TNNT2, TNNC1 GPR119 804/4885L3MBTL3 2317/4885L3MBTL1 2461/4885
US-20110144067-A1 N-Acyloxysulfonamide and N-Hydroxy-N-Acylsulfonamide Derivatives TNNI3, TNNT2, TNNC1 GPR119 804/4885L3MBTL3 2317/4885L3MBTL1 2461/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.