Sugi Predict

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SCHEMBL2024375

SCHEMBL2024375

CC(C)(C)OC(=O)N(OC(=O)N1CCC(N2CCOCC2)CC1)S(=O)(=O)c1ccccc1S(C)(=O)=O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 7/20 0.42
▸ ACHE P22303 1/20 0.41
▸ RECQL P46063 1/20 0.39
▸ L3MBTL3 Q96JM7 1/20 0.39
▸ L3MBTL1 Q9Y468 1/20 0.39
▸ STS P08842 1/20 0.39
▸ KDM4E B2RXH2 1/20 0.38
▸ CBX7 O95931 1/20 0.38
▸ CDYL2 Q8N8U2 1/20 0.38
▸ CDYL Q9Y232 1/20 0.38
▸ CDY1; CDY1B Q9Y6F8 1/20 0.38
▸ TGFBR1 P36897 1/20 0.38
▸ USP30 Q70CQ3 1/20 0.38
▸ PIK3CA P42336 2/20 0.38
▸ PIK3CD O00329 1/20 0.37
▸ PIK3R2 O00459 1/20 0.37
▸ PIK3CB P42338 1/20 0.37
▸ PIK3CG P48736 1/20 0.37
▸ PIK3R5 Q8WYR1 1/20 0.37
▸ PIK3R3 Q92569 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1949117 0.91 SMN1; SMN2 (0.45) GPR119RECQLSTSKDM4E
SCHEMBL2021936 0.90 GPR119 (0.41) GPR119ACHEL3MBTL3L3MBTL1STS
SCHEMBL12546547 0.84 GPR119 (0.45) GPR119STS
SCHEMBL1925858 0.83 STS (0.45) GPR119STS
SCHEMBL1926148 0.82 ACHE (0.39) GPR119ACHEL3MBTL3L3MBTL1KDM4E
SCHEMBL1926954 0.82 GPR119 (0.39) GPR119STS
SCHEMBL1925298 0.81 MAPK1 (0.38) GPR119STS
SCHEMBL1926180 0.78 GPR119 (0.43) GPR119PIK3CA
SCHEMBL1927684 0.77 KAT2B (0.34) GPR119
SCHEMBL2028194 0.75 MAPK1 (0.44) GPR119L3MBTL1STSKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2509941-B1 N-ACYLATED HYDROXYLAMINE DERIVATIVES AND O-ACYLATED HYDROXYLAMINE DERIVATIVES UNIV JOHNS HOPKINS (US) 2019-01-23 — — EP disclosed
US-20180050985-A1 N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES THE JOHNS HOPKINS UNIVERSITY 2018-02-22 — — US disclosed
US-20160046570-A1 N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES THE JOHNS HOPKINS UNIVERSITY 2016-02-18 — — US disclosed
US-20140235636-A1 N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES CARDIOXYL PHARMACEUTICALS, INC. (US) 2014-08-21 — — US disclosed
US-20110144067-A1 N-Acyloxysulfonamide and N-Hydroxy-N-Acylsulfonamide Derivatives THE JOHNS HOPKINS UNIVERSITY 2011-06-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140235636-A1 N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES TNNI3, TNNT2, TNNC1 GPR119 804/4885ACHE 2134/4885RECQL 1435/4885
US-20180050985-A1 N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES TNNI3, TNNT2, NOS2 GPR119 800/4885ACHE 2076/4885RECQL 1463/4885
US-20160046570-A1 N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES TNNI3, TNNT2, TNNC1 GPR119 804/4885ACHE 2134/4885RECQL 1435/4885
US-20110144067-A1 N-Acyloxysulfonamide and N-Hydroxy-N-Acylsulfonamide Derivatives TNNI3, TNNT2, TNNC1 GPR119 804/4885ACHE 2134/4885RECQL 1435/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.