Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 2/20 | 0.39 |
| ▸ | ATP4B | P51164 | 2/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.37 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15470033 | 0.88 | TLR8 (0.48) | ATP4AATP4BTLR7TLR8 | |
| SCHEMBL20219572 | 0.86 | CYP2D6 (0.43) | TLR7TLR8CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL23472265 | 0.83 | KDM4E (0.43) | TLR7TLR8CACNA1BCHRNB2CHRNB4 | |
| SCHEMBL20219756 | 0.83 | NOS1 (0.39) | ATP4AATP4BTLR7TLR8CACNA1B | |
| SCHEMBL20219386 | 0.83 | SCN9A (0.36) | TLR7TLR8TSHRSCN9A | |
| SCHEMBL20219430 | 0.82 | TLR7 (0.42) | TLR7TLR8 | |
| SCHEMBL20219479 | 0.81 | TLR7 (0.41) | TLR7TLR8 | |
| SCHEMBL20219346 | 0.80 | ALDH1A1 (0.40) | TLR7TLR8MAPTTSHR | |
| SCHEMBL23472190 | 0.80 | TLR7 (0.41) | TLR7TLR8 | |
| SCHEMBL20219381 | 0.80 | TLR8 (0.34) | TLR7TLR8TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |