Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 7/20 | 0.38 |
| ▸ | CX3CR1 | P49238 | 7/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20413269 | 0.82 | CX3CR1 (0.42) | CXCR2CX3CR1TRPM8CDK1TAS1R3 | |
| SCHEMBL15469950 | 0.81 | CX3CR1 (0.44) | CXCR2CX3CR1TRPM8ADORA1P2RX3 | |
| SCHEMBL20219573 | 0.79 | TLR7 (0.35) | TRPM8MITFLMNAMAPTSMN1; SMN2 | |
| SCHEMBL23472468 | 0.75 | TRPM8 (0.42) | TRPM8MITFLMNAMAPTSMN1; SMN2 | |
| SCHEMBL23472112 | 0.74 | TLR7 (0.34) | TRPM8MITFLMNAMAPTSMN1; SMN2 | |
| SCHEMBL20219410 | 0.72 | TRPM8 (0.46) | CXCR2CX3CR1TRPM8TAS1R3TAS1R1 | |
| SCHEMBL15469787 | 0.72 | TRPM8 (0.45) | TRPM8ADORA1P2RX3P2RX2 | |
| SCHEMBL20219351 | 0.72 | TLR8 (0.54) | TRPM8 | |
| SCHEMBL23472590 | 0.71 | STK17A (0.31) | — | |
| SCHEMBL20386616 | 0.70 | AGXT (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |