Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K7 | O14733 | 8/20 | 0.44 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.39 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.39 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.39 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20259228 | 0.87 | LMNA (0.41) | MAP2K7DGAT2ACACB | |
| SCHEMBL20239244 | 0.86 | DGAT2 (0.48) | DGAT2LTA4HEPHX2ACACBPLAAT3 | |
| SCHEMBL20239165 | 0.85 | DGAT2 (0.47) | DGAT2LTA4HEPHX2ACACBPLAAT3 | |
| SCHEMBL18249766 | 0.85 | PLAAT3 (0.44) | MAP2K7LTA4HEPHX2ACACBPLAAT3 | |
| SCHEMBL20239305 | 0.83 | DGAT2 (0.49) | MAP2K7DGAT2HDAC3HDAC1HDAC2 | |
| SCHEMBL20259122 | 0.83 | DGAT2 (0.45) | MAP2K7DGAT2GRIN1GRIN2BCYP3A4 | |
| SCHEMBL20239174 | 0.81 | LOXL2 (0.53) | MAP2K7EPHX2ACACBPLAAT3PLAAT5 | |
| SCHEMBL20259192 | 0.80 | DGAT2 (0.47) | DGAT2ACACBPLAAT3PLAAT5PLAAT2 | |
| SCHEMBL20239232 | 0.78 | DGAT2 (0.46) | DGAT2LTA4HEPHX2ACACBPLAAT3 | |
| SCHEMBL20239177 | 0.77 | DGAT2 (0.49) | DGAT2ACACBPLAAT3PLAAT5PLAAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3298001-B1 | DGAT2 INHIBITORS | LILLY CO ELI (US) | 2020-05-13 | — | — | EP | disclosed |
| US-10053429-B2 | DGAT2 inhibitors | ELI LILLY AND COMPANY (US) | 2018-08-21 | — | — | US | disclosed |
| US-20180162825-A1 | NOVEL DGAT2 INHIBITORS | ELI LILY AND COMPANY (US) | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162825-A1 | NOVEL DGAT2 INHIBITORS | DGAT2, DGAT1, LCAT | MAP2K7 4186/4885DGAT2 1/4885LTA4H 1212/4885 |
| US-10053429-B2 | DGAT2 inhibitors | DGAT2, DGAT1, LCAT | MAP2K7 4080/4885DGAT2 1/4885LTA4H 1134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.