Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | THRB | P10828 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20248957 | 0.90 | MAPK1 (0.73) | MAPK1ALDH1A1KMT2AMEN1THRB | |
| SCHEMBL20248943 | 0.88 | THRB (0.78) | MAPK1ALDH1A1KMT2AMEN1THRB | |
| SCHEMBL20248949 | 0.85 | MAPK1 (0.67) | MAPK1ALDH1A1KMT2AMEN1THRB | |
| SCHEMBL20248937 | 0.79 | KMT2A (0.73) | MAPK1ALDH1A1KMT2AMEN1THRB | |
| SCHEMBL20248942 | 0.76 | THRB (1.00) | MAPK1KMT2AMEN1THRBMAPT | |
| SCHEMBL20248933 | 0.76 | MAPT (0.70) | MAPK1ALDH1A1KMT2AMEN1THRB | |
| SCHEMBL20248944 | 0.74 | LMNA (0.66) | MAPK1ALDH1A1KMT2AMEN1THRB | |
| SCHEMBL20254573 | 0.74 | MAPT (0.67) | MAPK1ALDH1A1KMT2AMEN1THRB | |
| SCHEMBL13889175 | 0.71 | POLB (0.75) | MAPK1ALDH1A1KMT2AMEN1THRB | |
| SCHEMBL20248946 | 0.69 | LMNA (1.00) | ALDH1A1KMT2AMEN1THRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10253035-B2 | Eis inhibitors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2019-04-09 | — | — | US | disclosed |
| US-20180162867-A1 | EIS INHIBITORS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2018-06-14 | — | — | US | disclosed |
| US-20180162867-A1 | EIS INHIBITORS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162867-A1 | EIS INHIBITORS | EP300, ACAT1, ACAT2 | MAPK1 2924/4885ALDH1A1 1232/4885KMT2A 2491/4885 |
| US-10253035-B2 | Eis inhibitors | EP300, ACAT1, ACAT2 | MAPK1 2924/4885ALDH1A1 1232/4885KMT2A 2491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.