Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.71 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.71 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.71 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.71 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.71 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.71 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.71 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.70 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.70 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.70 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | PYGL | P06737 | 8/20 | 0.58 |
| ▸ | PYGM | P11217 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2031092 | 0.90 | KCNK2 (0.64) | MEN1KMT2APABPC1DUSP3PTPN5 | |
| SCHEMBL7787033 | 0.86 | KMT2A (0.72) | MEN1KMT2APABPC1DUSP3PTPN5 | |
| SCHEMBL2024937 | 0.86 | AKR1C4 (0.54) | MEN1KMT2APABPC1DUSP3PTPN5 | |
| SCHEMBL4092971 | 0.85 | KMT2A (0.71) | MEN1KMT2AAKR1C4AKR1C3AKR1C2 | |
| SCHEMBL2273640 | 0.85 | HDAC2 (0.67) | MEN1KMT2AAKR1C4AKR1C3AKR1C2 | |
| SCHEMBL13802484 | 0.84 | HTT (0.74) | MEN1KMT2AAKR1C4AKR1C3AKR1C2 | |
| SCHEMBL13802485 | 0.84 | SERPINE1 (0.59) | MEN1KMT2AAKR1C4AKR1C3AKR1C2 | |
| SCHEMBL13802483 | 0.84 | WDR5 (0.60) | MEN1KMT2APABPC1DUSP3PTPN5 | |
| SCHEMBL2273067 | 0.83 | HDAC2 (0.76) | MEN1KMT2AAKR1C4AKR1C3AKR1C2 | |
| SCHEMBL6349484 | 0.83 | AKR1C4 (0.78) | MEN1KMT2APABPC1DUSP3PTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2332528-A1 | Substituted aromatic dicarbonic acid amides as medicaments | Grünenthal GmbH (DE) | 2011-06-15 | — | — | EP | claimed |
| EP-2332528-A1 | Substituted aromatic dicarbonic acid amides as medicaments | Grünenthal GmbH (DE) | 2011-06-15 | — | — | EP | disclosed |
| EP-2332528-A1 | Substituted aromatic dicarbonic acid amides as medicaments | Grünenthal GmbH (DE) | 2011-06-15 | — | — | EP | disclosed |