Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C4 | P17516 | 1/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.54 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.54 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.54 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.54 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.54 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.54 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.54 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | PYGL | P06737 | 9/20 | 0.49 |
| ▸ | PYGM | P11217 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2024935 | 0.86 | MEN1 (0.71) | AKR1C4AKR1C3AKR1C2AKR1C1MEN1 | |
| SCHEMBL2031092 | 0.77 | KCNK2 (0.64) | AKR1C4AKR1C3AKR1C2AKR1C1MEN1 | |
| SCHEMBL4092971 | 0.75 | KMT2A (0.71) | AKR1C4AKR1C3AKR1C2AKR1C1MEN1 | |
| SCHEMBL2273640 | 0.75 | HDAC2 (0.67) | AKR1C4AKR1C3AKR1C2AKR1C1MEN1 | |
| SCHEMBL7787033 | 0.74 | KMT2A (0.72) | AKR1C4AKR1C3AKR1C2AKR1C1MEN1 | |
| SCHEMBL2273067 | 0.74 | HDAC2 (0.76) | AKR1C4AKR1C3AKR1C2AKR1C1MEN1 | |
| SCHEMBL2272594 | 0.72 | PYGL (0.72) | MEN1KMT2APYGLPYGMMAPT | |
| SCHEMBL27696967 | 0.72 | SNCA (0.64) | AKR1C4AKR1C3AKR1C2AKR1C1MEN1 | |
| SCHEMBL2271993 | 0.72 | ALDH1A1 (0.61) | AKR1C4AKR1C3AKR1C2AKR1C1MEN1 | |
| SCHEMBL13802485 | 0.72 | SERPINE1 (0.59) | AKR1C4AKR1C3AKR1C2AKR1C1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2332528-A1 | Substituted aromatic dicarbonic acid amides as medicaments | Grünenthal GmbH (DE) | 2011-06-15 | — | — | EP | disclosed |