Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28918928 | 0.80 | PDE2A (0.47) | PDE2AALDH1A1MAPTPPARD | |
| SCHEMBL23912779 | 0.79 | PDE2A (0.46) | PDE2AALDH1A1MAPTMCL1PPARD | |
| SCHEMBL20072565 | 0.77 | PDE2A (0.44) | PDE2AALDH1A1MAPTMCL1PPARD | |
| SCHEMBL29402881 | 0.71 | TSHR (0.61) | PDE2AALDH1A1MAPTMCL1 | |
| SCHEMBL980201 | 0.71 | TSHR (0.61) | PDE2AALDH1A1MAPTMCL1 | |
| SCHEMBL23048501 | 0.70 | HAO1 (0.42) | ALDH1A1 | |
| SCHEMBL11265653 | 0.69 | PDE7A (0.45) | PDE2AALDH1A1MAPTMRGPRX4 | |
| SCHEMBL19785361 | 0.69 | PDE2A (0.52) | PDE2AALDH1A1MAPT | |
| Ammonia Solution, Strong SCHEMBL28020319 | 0.69 | TSHR (0.58) | PDE2AALDH1A1MAPTMCL1 | |
| SCHEMBL3161607 | 0.68 | ALDH1A1 (0.53) | PDE2AALDH1A1MAPTMCL1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3548475-B1 | SULFONAMIDE ANALOGUES OF GALIELLALACTONE | GLACTONE PHARMA DEV AB (SE) | 2021-03-03 | — | — | EP | disclosed |
| WO-2018104295-A1 | SULFONAMIDE ANALOGUES OF GALIELLALACTONE | GLACTONE PHARMA DEVELOPMENT AB (SE) | 2018-06-14 | — | — | WO | disclosed |