Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL277595 | 0.71 | METAP2 (0.47) | METAP2METAP1NPY5R | |
| Purine SCHEMBL763130 | 0.70 | LMNA (0.35) | ALDH1A1KDM4ELMNA | |
| SCHEMBL19094567 | 0.69 | NOS3 (0.40) | ALDH1A1KDM4EHSD17B10MAPKAPK2RPS6KA3 | |
| SCHEMBL329703 | 0.69 | METAP2 (0.43) | METAP2METAP1NPY5R | |
| SCHEMBL927587 | 0.69 | NUDT1 (0.48) | METAP2METAP1KDM4EMAPKAPK2RPS6KA3 | |
| SCHEMBL4146190 | 0.69 | SMN1; SMN2 (0.55) | ALDH1A1KDM4EHSD17B10MAPKAPK2RPS6KA3 | |
| SCHEMBL30891689 | 0.69 | PDE3B (0.44) | ALDH1A1MAPKAPK2RPS6KA3CSNK2A1PLK3 | |
| SCHEMBL4297906 | 0.69 | AURKA (0.43) | ALDH1A1KDM4EHSD17B10MAPKAPK2RPS6KA3 | |
| SCHEMBL3020577 | 0.69 | MAPKAPK2 (0.41) | ALDH1A1KDM4EHSD17B10MAPKAPK2RPS6KA3 | |
| SCHEMBL8354989 | 0.68 | METAP2 (0.42) | METAP2METAP1NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854419-A | Tricyclic pteridinones and a process for their preparation | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-12-29 | — | — | US | claimed |
| CN-120020133-A | Nitrogen-containing heterocyclic derivative and medical application thereof | 杭州百新生物医药科技有限公司 | 2025-05-20 | — | — | CN | disclosed |
| WO-2025096494-A1 | UBIQUITIN SPECIFIC PROCESSING PROTEASE 1 (USP1) COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-05-08 | — | — | WO | disclosed |
| CN-119930632-A | Tri-ring ubiquitin-specific protease 1 inhibitor, and preparation method, application and pharmaceutical composition thereof | 中国医学科学院药物研究所 | 2025-05-06 | — | — | CN | disclosed |
| CN-119930633-A | Pyrrolopyrrolidone ubiquitin specific protease 1 inhibitor, and preparation method, application and pharmaceutical composition thereof | 中国医学科学院药物研究所 | 2025-05-06 | — | — | CN | disclosed |
| CN-115813928-B | Arginine methyltransferase PRMT1 inhibitor and application thereof | 厦门大学 | 2025-03-11 | — | — | CN | disclosed |
| CN-117402160-A | Wnt pathway inhibitor compound | 杭州阿诺生物医药科技有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-115043840-A | Methods for preparing TOLL-like receptor modulators | 吉利德科学公司 | 2022-09-13 | — | — | CN | disclosed |
| CN-107074860-B | Methods for preparing TOLL-like receptor modulators | 吉利德科学公司 | 2022-07-15 | — | — | CN | disclosed |
| EP-2920178-A1 | NOVEL HETEROCYCLIC DERIVATIVES AS MODULATORS OF KINASE ACTIVITY | Merck Patent GmbH (DE) | 2015-09-23 | — | — | EP | disclosed |
| CN-101686981-A | Diazo bicyclic SMAC mimetics and uses thereof | UNIV MICHIGAN | 2010-03-31 | — | — | CN | disclosed |
| CN-101171241-A | Chromen-4-one inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | UNIV MICHIGAN (US) | 2008-04-30 | — | — | CN | disclosed |
| CN-101132783-A | Apogossypolone and the uses thereof | UNIV MICHIGAN (US) | 2008-02-27 | — | — | CN | disclosed |
| CN-1960719-A | Gossypol co-crystals and the use thereof | UNIV MICHIGAN (US) | 2007-05-09 | — | — | CN | disclosed |
| CN-1960728-A | Conformationally constrained SMAC mimetics and uses thereof | UNIV MICHIGAN (US) | 2007-05-09 | — | — | CN | disclosed |
| CN-1933847-A | SMAC peptidomimetics and the uses thereof | UNIV MICHIGAN (US) | 2007-03-21 | — | — | CN | disclosed |
| EP-1066286-A4 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2004-02-11 | — | — | EP | disclosed |
| EP-1066286-A1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-01-10 | — | — | EP | disclosed |
| WO-1999045009-A1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-09-10 | — | — | WO | disclosed |
| US-5854419-A | Tricyclic pteridinones and a process for their preparation | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-12-29 | — | — | US | disclosed |