Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 13/20 | 0.43 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | PHGDH | O43175 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680837 | 0.93 | CNR1 (0.42) | GPR88UTS2RCNR1PHGDH | |
| SCHEMBL680232 | 0.83 | TAS1R3 (0.43) | UTS2RCNR1 | |
| SCHEMBL12188442 | 0.81 | CNR1 (0.44) | GPR88UTS2RCNR1PHGDH | |
| SCHEMBL10258482 | 0.78 | CNR1 (0.44) | UTS2RCNR1PHGDH | |
| SCHEMBL681345 | 0.74 | FFAR2 (0.43) | CNR1 | |
| SCHEMBL680703 | 0.72 | CYP2D6 (0.58) | — | |
| SCHEMBL2439835 | 0.71 | POLB (0.53) | GPR88 | |
| SCHEMBL14197228 | 0.70 | GPR88 (0.49) | GPR88UTS2RPHGDH | |
| SCHEMBL21490939 | 0.70 | EPHX2 (0.48) | — | |
| SCHEMBL21490940 | 0.70 | EPHX2 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180169099-A1 | HYDROXYLATED AND METHOXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2018-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180169099-A1 | HYDROXYLATED AND METHOXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | AKT1, AKT2, AKT1S1 | GPR88 1753/4885UTS2R 2187/4885CNR1 2540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.