Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | CASR | P41180 | 1/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 7/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12188442 | 0.87 | CNR1 (0.44) | CNR1KDM4EGAAPHGDHCNR2 | |
| SCHEMBL680837 | 0.85 | CNR1 (0.42) | CNR1KDM4EGAAPHGDHUTS2R | |
| SCHEMBL20282975 | 0.78 | GPR88 (0.43) | CNR1PHGDHUTS2R | |
| SCHEMBL680232 | 0.75 | TAS1R3 (0.43) | CNR1KDM4EGAACNR2CASR | |
| SCHEMBL9363415 | 0.72 | EPHX1 (0.49) | CNR1EPHX1THRBCASRMEN1 | |
| SCHEMBL2738729 | 0.72 | P2RX7 (0.41) | — | |
| SCHEMBL28419253 | 0.71 | CYP2C9 (0.49) | EPHX1THRBMEN1KMT2A | |
| SCHEMBL21979535 | 0.71 | KDM4E (0.47) | CNR1KDM4EGAAPHGDHCNR2 | |
| SCHEMBL21979517 | 0.71 | KDM4E (0.47) | CNR1KDM4EGAAPHGDHCNR2 | |
| SCHEMBL4826506 | 0.71 | GABBR2 (0.46) | EPHX1THRBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402325-A2 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as AKT protein kinase inhibitors | Array Biopharma, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| EP-2399909-A1 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as akt protein kinase inhibitors | Array Biopharma, Inc. (US) | 2011-12-28 | — | — | EP | disclosed |