Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | UTS2R | Q9UKP6 | 8/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680837 | 0.90 | CNR1 (0.42) | CNR1UTS2RKDM4EGAACYP1A2 | |
| SCHEMBL20282975 | 0.83 | GPR88 (0.43) | CNR1UTS2R | |
| SCHEMBL681345 | 0.82 | FFAR2 (0.43) | CNR1KDM4EGAACYP1A2CYP2D6 | |
| SCHEMBL9661755 | 0.80 | LMNA (0.51) | TAS1R3TAS1R1CNR1CYP1A2CYP2D6 | |
| SCHEMBL12188442 | 0.78 | CNR1 (0.44) | CNR1UTS2RKDM4EGAACASR | |
| SCHEMBL10258482 | 0.75 | CNR1 (0.44) | CNR1UTS2RKDM4EGAACASR | |
| SCHEMBL681425 | 0.74 | FFAR2 (0.44) | ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL680703 | 0.73 | CYP2D6 (0.58) | KDM4ECYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL681427 | 0.73 | BCL2A1 (0.40) | GAAKCNQ2SMN1; SMN2 | |
| SCHEMBL679779 | 0.73 | FFAR2 (0.43) | KDM4ECYP1A2CYP2D6CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |