SCHEMBL202848

SCHEMBL202848

Cc1csc(COc2ccc(F)c(C(N)=O)c2F)c1

nearest known ligand 0.49

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TNKS2 Q9H2K2 1/20 0.37
LMNA P02545 1/20 0.36
HTT P42858 1/20 0.36
MRGPRX4 Q96LA9 4/20 0.34
PRKCZ Q05513 2/20 0.33
PRSS1 P07477 1/20 0.33
TMPRSS15 P98073 1/20 0.33
PTGER1 P34995 1/20 0.33
PARP1 P09874 3/20 0.33
RAB9A P51151 1/20 0.32
AKR1C1 Q04828 1/20 0.32
KDR P35968 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19471072 0.81 ALAD (0.39) MRGPRX4PTGER1
SCHEMBL202843 0.79 TNKS2 (0.36) TNKS2LMNAHTTMRGPRX4KDR
SCHEMBL202084 0.78 SLC1A3 (0.41) LMNAHTT
SCHEMBL202507 0.78 MRGPRX4 (0.53) LMNAHTTMRGPRX4
SCHEMBL2705638 0.77 LMNA (0.48) TNKS2LMNAHTTMRGPRX4PARP1
SCHEMBL201928 0.77 NPC1 (0.38) TNKS2LMNARAB9A
SCHEMBL200936 0.77 HTR2A (0.43) LMNAHTTRAB9A
SCHEMBL201275 0.76 ALOX5 (0.40) LMNAHTTMRGPRX4RAB9A
SCHEMBL201298 0.76 PARP15 (0.55) LMNAHTTRAB9A
SCHEMBL203686 0.76 PTGER1 (0.42) PTGER1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250179008-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. (US) 2025-06-05 US disclosed
US-20150191420-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. 2015-07-09 US disclosed
US-20150191420-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. 2015-07-09 US disclosed
US-20150191420-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. 2015-07-09 US disclosed
US-8865736-B2 Antibacterial agents Biota Scientific Pty Ltd (AU) 2014-10-21 US disclosed
US-8865736-B2 Antibacterial agents Biota Scientific Pty Ltd (AU) 2014-10-21 US disclosed
US-20130072520-A2 ANTIBACTERIAL AGENTS BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2013-03-21 US disclosed
US-20130072520-A2 ANTIBACTERIAL AGENTS BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2013-03-21 US disclosed
US-20120122918-A1 ANTIBACTERIAL AGENTS BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2012-05-17 US disclosed
US-20120122918-A1 ANTIBACTERIAL AGENTS BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2012-05-17 US disclosed
US-20120122918-A1 ANTIBACTERIAL AGENTS BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2012-05-17 US disclosed
US-8088791-B2 Antibacterial agents Biots Scientific Management Pty Ltd (AU) 2012-01-03 US disclosed
US-8088791-B2 Antibacterial agents Biots Scientific Management Pty Ltd (AU) 2012-01-03 US disclosed
US-8088791-B2 Antibacterial agents Biots Scientific Management Pty Ltd (AU) 2012-01-03 US disclosed
EP-1996180-B1 BENZAMIDE AND PYRIDYLAMIDE DERIVATIVES AS ANTIBACTERIAL AGENTS BIOTA EUROPE LTD (GB) 2011-08-03 EP disclosed
EP-1996180-B1 BENZAMIDE AND PYRIDYLAMIDE DERIVATIVES AS ANTIBACTERIAL AGENTS BIOTA EUROPE LTD (GB) 2011-08-03 EP disclosed
US-20100173933-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2010-07-08 US disclosed
US-20100173933-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2010-07-08 US disclosed
US-20100173933-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2010-07-08 US disclosed
WO-2007107758-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2007-09-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120122918-A1 ANTIBACTERIAL AGENTS ALK, ROS1, ARG1 TNKS2 2785/4885LMNA 3250/4885HTT 4308/4885
US-20130072520-A2 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 TNKS2 4145/4885LMNA 1817/4885HTT 4286/4885
US-20150191420-A1 ANTIBACTERIAL AGENTS ALK, ARG1, ROS1 TNKS2 2405/4885LMNA 2877/4885HTT 4291/4885
US-20250179008-A1 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 TNKS2 4145/4885LMNA 1817/4885HTT 4286/4885
US-20100173933-A1 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 TNKS2 4145/4885LMNA 1817/4885HTT 4286/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.