Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 9/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20288815 | 0.82 | CYP11B2 (0.50) | CYP11B2CYP11B1NOTUMTP53SYK | |
| SCHEMBL20288496 | 0.80 | NOTUM (0.51) | CYP11B2CYP11B1NOTUMTP53ALDH1A1 | |
| SCHEMBL18871772 | 0.78 | CYP11B2 (0.54) | CYP11B2CYP11B1NOTUMTP53ALDH1A1 | |
| SCHEMBL18114135 | 0.75 | RAB9A (0.67) | CYP11B2CYP11B1NOTUMTP53ALDH1A1 | |
| SCHEMBL20288525 | 0.75 | PDK1 (0.69) | CYP11B2CYP11B1NOTUMTP53PDK1 | |
| SCHEMBL18871768 | 0.75 | CYP11B1 (0.58) | CYP11B2CYP11B1NOTUMTP53ALDH1A1 | |
| SCHEMBL20288819 | 0.74 | CYP11B2 (0.47) | CYP11B2CYP11B1NOTUMTP53ALDH1A1 | |
| SCHEMBL18871984 | 0.74 | CYP11B2 (0.56) | CYP11B2CYP11B1NOTUMTP53PDK1 | |
| SCHEMBL18871771 | 0.74 | CYP11B2 (0.53) | CYP11B2CYP11B1NOTUMTP53PDK1 | |
| SCHEMBL25045648 | 0.73 | CYP11B1 (0.57) | CYP11B2CYP11B1NOTUMSYKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018111805-A1 | TETRAHYDROQUINOLINE-BASED BROMODOMAIN INHIBITORS | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2018-06-21 | — | — | WO | disclosed |