Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.49 |
| ▸ | HPGDS | O60760 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6852749 | 0.85 | KDM4E (0.57) | KDM4EPOLBSMN1; SMN2MAPK10HTT | |
| SCHEMBL10172622 | 0.83 | KDM4E (0.56) | KDM4EPOLBSMN1; SMN2MAPK10HTT | |
| SCHEMBL10642212 | 0.83 | LMNA (0.44) | KDM4ESMN1; SMN2ALDH1A1HPGDKMT2A | |
| SCHEMBL21331813 | 0.82 | KDM4E (0.55) | KDM4EPOLBSMN1; SMN2MAPK10HTT | |
| SCHEMBL29720381 | 0.80 | MEN1 (0.42) | KDM4ESMN1; SMN2ALDH1A1KMT2AGAA | |
| SCHEMBL11204630 | 0.77 | KDM4E (0.49) | KDM4EPOLBSMN1; SMN2MAPK10HTT | |
| SCHEMBL19209480 | 0.76 | PDE4D (0.59) | KDM4ESMN1; SMN2MAPK10HTTHPGDS | |
| SCHEMBL16260565 | 0.76 | KDM4E (0.57) | KDM4EPOLBSMN1; SMN2TARBP2HPGDS | |
| SCHEMBL20075637 | 0.74 | GABRA2 (0.43) | KDM4EPOLBSMN1; SMN2MAPK10HTT | |
| SCHEMBL7440553 | 0.73 | KDM4E (0.56) | KDM4ESMN1; SMN2MAPK10TARBP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805939-B1 | Heterocyclic compounds as factor IXA inhibitors. | MERCK SHARP & DOHME (US) | 2018-06-27 | — | — | EP | disclosed |