Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 12/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21337688 | 0.80 | KIF11 (0.44) | KIF11KDM1APTGS2CYP11B1CYP11B2 | |
| SCHEMBL27305620 | 0.78 | NOTUM (0.35) | — | |
| SCHEMBL20226666 | 0.75 | ALDH1A1 (0.42) | — | |
| SCHEMBL5761306 | 0.75 | KDM1A (0.36) | KDM1A | |
| SCHEMBL27324391 | 0.74 | CES2 (0.39) | DAO | |
| SCHEMBL27294518 | 0.72 | CES2 (0.37) | — | |
| SCHEMBL20384257 | 0.71 | CYP1A2 (0.36) | — | |
| SCHEMBL2653697 | 0.71 | TSHR (0.39) | PTGS2 | |
| SCHEMBL776830 | 0.69 | ACHE (0.36) | — | |
| SCHEMBL12706035 | 0.68 | KIF11 (0.53) | KIF11KDM1ACYP11B1CYP11B2DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3851107-A1 | HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | Corcept Therapeutics Incorporated (US) | 2021-07-21 | — | — | EP | disclosed |
| EP-3848027-A1 | OCTAHYDRO FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | Corcept Therapeutics Incorporated (US) | 2021-07-14 | — | — | EP | disclosed |
| EP-3560493-A1 | OCTAHYDRO FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | Corcept Therapeutics Incorporated (US) | 2019-10-30 | — | — | EP | disclosed |
| EP-3074011-B1 | OCTAHYDRO FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | CORCEPT THERAPEUTICS INC (US) | 2019-07-24 | — | — | EP | disclosed |
| EP-3338781-A1 | HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | Corcept Therapeutics, Inc. (US) | 2018-06-27 | — | — | EP | disclosed |