Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SNCA | P37840 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20314813 | 0.79 | CYP3A4 (0.50) | TRPM8ALDH1A1GLATSHRMEN1 | |
| SCHEMBL9716632 | 0.79 | CYP3A4 (0.50) | TRPM8ALDH1A1GLATSHRMEN1 | |
| SCHEMBL9716636 | 0.79 | CYP3A4 (0.50) | TRPM8ALDH1A1GLATSHRMEN1 | |
| SCHEMBL20314812 | 0.79 | TRPM8 (0.46) | TRPM8ALDH1A1GLATSHRMEN1 | |
| SCHEMBL9405499 | 0.79 | TRPM8 (0.46) | TRPM8ALDH1A1GLATSHRMEN1 | |
| SCHEMBL4235763 | 0.78 | TRPM8 (0.58) | TRPM8ALDH1A1SNCAMEN1NPC1 | |
| SCHEMBL10220933 | 0.78 | TRPM8 (0.69) | TRPM8ALDH1A1GLANPC1 | |
| SCHEMBL2992708 | 0.75 | GSTO1 (0.54) | TRPM8ALDH1A1GLATSHRMEN1 | |
| SCHEMBL547256 | 0.72 | ALDH1A1 (0.52) | TRPM8ALDH1A1GLATSHRMEN1 | |
| SCHEMBL11315866 | 0.70 | ALDH1A1 (0.50) | ALDH1A1GLATSHRMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10669289-B2 | Boronic acid derivatives | MERCK PATENT GMBH (DE) | 2020-06-02 | — | — | US | disclosed |
| US-20180179232-A1 | BORONIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-06-28 | — | — | US | disclosed |
| US-20180179232-A1 | BORONIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10669289-B2 | Boronic acid derivatives | BCL9, BCL9L, BCL6 | TRPM8 4013/4885ALDH1A1 1217/4885GLA 1983/4885 |
| US-20180179232-A1 | BORONIC ACID DERIVATIVES | BCL9, BCL9L, BCL6 | TRPM8 4013/4885ALDH1A1 1217/4885GLA 1983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.