Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALB | P02768 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.44 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | RNASEL | Q05823 | 5/20 | 0.41 |
| ▸ | DTYMK | P23919 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20325230 | 0.95 | STING1 (0.46) | ALDH1A1LMNAALBMAPK1STING1 | |
| SCHEMBL18521967 | 0.88 | P2RX3 (0.59) | ALDH1A1P2RX3RNASELDTYMK | |
| SCHEMBL18510949 | 0.88 | P2RX3 (0.59) | ALDH1A1P2RX3RNASELDTYMK | |
| SCHEMBL21540016 | 0.87 | ALDH1A1 (0.51) | ALDH1A1LMNAALBMAPK1STING1 | |
| SCHEMBL21539917 | 0.87 | ALDH1A1 (0.51) | ALDH1A1LMNAALBMAPK1STING1 | |
| SCHEMBL20327051 | 0.87 | RNASEL (0.43) | STING1P2RX3RNASELDTYMK | |
| SCHEMBL20325281 | 0.87 | ALDH1A1 (0.46) | ALDH1A1LMNAALBMAPK1P2RX3 | |
| SCHEMBL22399293 | 0.83 | RNASEL (0.49) | STING1P2RX3RNASEL | |
| SCHEMBL20325247 | 0.82 | FUT5 (0.50) | STING1RNASELDTYMK | |
| SCHEMBL20324882 | 0.81 | RNASEL (0.56) | P2RX3RNASEL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018118664-A1 | COMBINATIONS OF PD-1 ANTAGONISTS AND CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |