Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 2/20 | 0.34 |
| ▸ | TTR | P02766 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876801 | 0.98 | ALDH1A1 (0.44) | ALDH1A1TDP1TP53CYP3A4MAPT | |
| SCHEMBL7759021 | 0.98 | ALDH1A1 (0.44) | ALDH1A1TDP1TP53CYP3A4MAPT | |
| SCHEMBL6571930 | 0.90 | GABRA1 (0.39) | ALDH1A1TDP1TP53CYP3A4MAPT | |
| SCHEMBL2427389 | 0.90 | GABRA1 (0.39) | ALDH1A1TDP1TP53CYP3A4MAPT | |
| SCHEMBL6573320 | 0.90 | TP53 (0.46) | TDP1TP53CYP3A4MAPTALOX15 | |
| SCHEMBL6573426 | 0.90 | TP53 (0.46) | TDP1TP53CYP3A4MAPTALOX15 | |
| SCHEMBL6573201 | 0.90 | TP53 (0.46) | TDP1TP53CYP3A4MAPTALOX15 | |
| SCHEMBL6876844 | 0.84 | CYP1A2 (0.53) | ALDH1A1MAPTMAPK1SMN1; SMN2CYP1A2 | |
| SCHEMBL6884409 | 0.84 | CYP1A2 (0.53) | ALDH1A1MAPTMAPK1SMN1; SMN2CYP1A2 | |
| SCHEMBL2029883 | 0.82 | PTGS1 (0.58) | TDP1TP53CYP3A4MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960557-B2 | Asymmetric dendrimers | ISIS INNOVATION LIMITED (GB) | 2011-06-14 | — | — | US | disclosed |
| US-20090326238-A1 | ASYMMETRIC DENDRIMERS | ISIS INNOVATION LIMITED (GB) | 2009-12-31 | — | — | US | disclosed |
| US-7537842-B2 | Asymmetric dendrimers | ISIS INNOVATION LIMITED (GB) | 2009-05-26 | — | — | US | disclosed |
| EP-1373431-B1 | ASYMMETRIC DENDRIMERS | ISIS INNOVATION (GB) | 2006-10-18 | — | — | EP | disclosed |
| US-20040110029-A1 | Asymmetric dendrimers | CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326238-A1 | ASYMMETRIC DENDRIMERS | DNM2, DYNLL2, DNM1 | ALDH1A1 1358/4885TDP1 2365/4885TP53 4264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.