Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 10/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 10/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20233723 | 0.91 | ADRB2 (0.48) | HPGDSMN1; SMN2ADRB2CA4TSHR | |
| SCHEMBL20133267 | 0.91 | TAS1R3 (0.47) | TAS1R3TAS1R1HPGDSMN1; SMN2LMNA | |
| SCHEMBL18592286 | 0.89 | TAS1R3 (0.50) | TAS1R3TAS1R1HPGDSMN1; SMN2FLT3 | |
| SCHEMBL20235084 | 0.89 | TAS1R3 (0.47) | TAS1R3TAS1R1HPGDSMN1; SMN2LMNA | |
| SCHEMBL15623151 | 0.86 | LMNA (0.51) | TAS1R3TAS1R1HPGDSMN1; SMN2LMNA | |
| SCHEMBL20234807 | 0.86 | ADRB2 (0.51) | TAS1R3TAS1R1KDM4EALDH1A1ADRB2 | |
| SCHEMBL18592287 | 0.86 | ADRB2 (0.51) | TAS1R3TAS1R1KDM4EALDH1A1FLT3 | |
| SCHEMBL18611776 | 0.85 | KDM4E (0.50) | TAS1R3TAS1R1HPGDSMN1; SMN2LMNA | |
| SCHEMBL11751622 | 0.82 | ADRB2 (0.56) | LMNAKDM4EGLAADRB2TSHR | |
| SCHEMBL15623155 | 0.82 | ALDH1A1 (0.55) | TAS1R3TAS1R1HPGDSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018140809-A1 | MODULATORS OF ESTROGEN RECEPTOR PROTEOLYSIS AND ASSOCIATED METHODS OF USE | Arvinas, Inc. (US) | 2018-08-02 | — | — | WO | disclosed |
| WO-2018119357-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ENHANCER OF ZESTE HOMOLOG 2 POLYPEPTIDE | Arvinas, Inc. (US) | 2018-06-28 | — | — | WO | disclosed |