SCHEMBL2033573

SCHEMBL2033573

C=CC(=O)OC(C)N1C(=O)c2ccccc2C1=O

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.46
ALDH1A1 P00352 4/20 0.46
HTT P42858 3/20 0.46
TSHR P16473 1/20 0.43
NPC1 O15118 1/20 0.41
TP53 P04637 1/20 0.41
POLB P06746 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
GAA P10253 1/20 0.40
KMT2A Q03164 1/20 0.40
ALOX15 P16050 1/20 0.40
MAPK1 P28482 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
MAPT P10636 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9838175 0.81 LMNA (0.40) LMNAALDH1A1TP53POLBGAA
SCHEMBL21694483 0.81 NPSR1 (0.46) ALDH1A1POLBKMT2AMAPK1MAPT
SCHEMBL17916043 0.80 LMNA (0.51) LMNAALDH1A1HTTNPC1TP53
SCHEMBL2030887 0.78 LMNA (0.46) LMNAALDH1A1HTTNPC1TP53
SCHEMBL28034445 0.77 TSHR (0.36) ALDH1A1TSHR
SCHEMBL13266067 0.77 ALDH1A1 (0.46) LMNAALDH1A1HTTTSHRNPC1
SCHEMBL11576351 0.76 LMNA (0.47) LMNAALDH1A1HTTTSHRNPC1
SCHEMBL1147828 0.76 TSHR (0.33) TSHR
SCHEMBL29260872 0.76 L3MBTL1 (0.45) LMNAALDH1A1HTTTP53POLB
SCHEMBL29260869 0.76 TDP1 (0.46) LMNAALDH1A1HTTTSHRPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107428891-B Curable composition 施敏打硬株式会社 2021-04-20 CN disclosed
EP-3004050-B1 CYANOSTILBENES ROLIC TECH AG (CH) 2020-09-02 EP disclosed
CN-111533668-A Cyanostilbenes 罗利克技术有限公司 2020-08-14 CN disclosed
US-10329486-B2 Cyanostilbenes ROLIC AG (CH) 2019-06-25 US disclosed
CN-105567260-B Functionalized photoreactive compounds 罗利克有限公司 2018-09-11 CN disclosed
EP-3004050-A1 CYANOSTILBENES Rolic AG (CH) 2016-04-13 EP disclosed
US-20160083655-A1 CYANOSTILBENES ROLIC AG (CH) 2016-03-24 US disclosed
WO-2014191292-A1 CYANOSTILBENES ROLIC AG (CH) 2014-12-04 WO disclosed
US-7959990-B2 Adjustment of liquid crystals; oligomers, dendrimers, or polymer in solution is applied to support; crosslinking by radiation or polarized light ROLIC AG (CH) 2011-06-14 US disclosed
EP-1928979-B1 FUNCTIONALIZED PHOTOREACTIVE COMPOUNDS ROLIC AG (CH) 2009-03-04 EP disclosed
US-20080274304-A1 Functionalized Photoreactive Compounds ROLIC AG (CH) 2008-11-06 US disclosed
EP-1764405-A1 Functionalized photoreactive compounds Rolic AG (CH) 2007-03-21 EP disclosed
US-4985328-A Metal Complex Charge Control Agents HITACHI CHEMICAL CO., LTD. (JP) 1991-01-15 US disclosed
EP-0360617-A2 Dry toner, dry developer and process for forming images Hitachi Chemical Co., Ltd. (JP) 1990-03-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080274304-A1 Functionalized Photoreactive Compounds PCNA, PIN1, MAP1LC3C LMNA 1132/4885ALDH1A1 147/4885HTT 4286/4885
US-20160083655-A1 CYANOSTILBENES LATS1, LATS2, CRY1 LMNA 166/4885ALDH1A1 2838/4885HTT 2226/4885
US-10329486-B2 Cyanostilbenes LATS1, LATS2, CRY1 LMNA 166/4885ALDH1A1 2838/4885HTT 2226/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.