Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 5/20 | 0.41 |
| ▸ | DRD4 | P21917 | 5/20 | 0.41 |
| ▸ | DRD3 | P35462 | 5/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | BDKRB2 | P30411 | 2/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20340374 | 0.85 | OPRM1 (0.48) | OPRM1OPRD1OPRK1OPRL1DRD2 | |
| SCHEMBL20340400 | 0.85 | OPRM1 (0.48) | OPRM1OPRD1OPRK1OPRL1DRD2 | |
| SCHEMBL18961829 | 0.84 | OPRL1 (0.64) | OPRM1OPRD1OPRK1OPRL1DRD2 | |
| SCHEMBL20340381 | 0.84 | DRD2 (0.49) | OPRM1OPRD1OPRK1OPRL1DRD2 | |
| SCHEMBL18961830 | 0.83 | ENPP2 (0.48) | OPRM1OPRD1OPRK1OPRL1DRD2 | |
| SCHEMBL20340396 | 0.82 | OPRM1 (0.49) | OPRM1OPRD1OPRK1OPRL1DRD2 | |
| SCHEMBL20340373 | 0.81 | OPRM1 (0.45) | OPRM1OPRD1OPRK1OPRL1DRD2 | |
| SCHEMBL20340376 | 0.81 | RAB9A (0.46) | OPRM1OPRD1OPRK1OPRL1DRD2 | |
| SCHEMBL20340399 | 0.81 | GFER (0.49) | OPRM1OPRD1OPRK1OPRL1DRD2 | |
| SCHEMBL20340444 | 0.80 | MAPT (0.44) | OPRM1OPRD1OPRK1OPRL1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10011601-B2 | Substituted spirocyclic inhibitors of autotaxin | X-RX, INC. (US) | 2018-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10011601-B2 | Substituted spirocyclic inhibitors of autotaxin | ENPP2, SLC10A1, CXCR3 | OPRM1 2568/4885OPRD1 823/4885OPRK1 770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.