Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | XIAP | P98170 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20347991 | 0.78 | LMNA (0.44) | ALDH1A1GFERLMNAATMPRCP | |
| SCHEMBL5315718 | 0.76 | CYP1A2 (0.54) | ALDH1A1LMNATP53CYP1A2CYP3A4 | |
| SCHEMBL3553167 | 0.74 | SIGMAR1 (0.46) | KMT2AALDH1A1MAPK1HTR2B | |
| SCHEMBL9171080 | 0.74 | CYP2B6 (0.39) | SRD5A1BRD4TSHRKMT2AALDH1A1 | |
| SCHEMBL21752126 | 0.74 | DRD1 (0.57) | MAPTMAPK1XIAP | |
| SCHEMBL20347981 | 0.73 | DDB1 (0.54) | TSHRKMT2AALDH1A1 | |
| SCHEMBL7213386 | 0.72 | MAPT (0.50) | ALDH1A1LMNATP53CYP1A2CYP3A4 | |
| SCHEMBL20347921 | 0.71 | CES2 (0.47) | TSHRKMT2A | |
| SCHEMBL16203621 | 0.70 | TSHR (0.53) | SRD5A1BRD4TSHRKMT2ACHRNB2 | |
| SCHEMBL15203830 | 0.70 | TSHR (0.53) | SRD5A1BRD4TSHRKMT2ACHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210340107-A1 | NRF2 ACTIVATOR | BIOGEN MA INC. | 2021-11-04 | — | — | US | disclosed |
| EP-3875450-A1 | NRF2 ACTIVATOR | Biogen MA Inc. (US) | 2021-09-08 | — | — | EP | disclosed |
| US-10968181-B2 | NRF2 activator | BIOGEN MA INC. (US) | 2021-04-06 | — | — | US | disclosed |
| EP-3562816-B1 | NRF2 ACTIVATOR | BIOGEN MA INC (US) | 2021-01-20 | — | — | EP | disclosed |
| US-20190345112-A1 | NRF2 ACTIVATOR | BIOGEN MA INC. | 2019-11-14 | — | — | US | disclosed |
| WO-2018125880-A1 | NRF2 ACTIVATOR | BIOGEN MA INC. (US) | 2018-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190345112-A1 | NRF2 ACTIVATOR | NFE2L2, KEAP1, NQO1 | SRD5A1 1473/4885BRD4 2509/4885TSHR 3246/4885 |
| US-20210340107-A1 | NRF2 ACTIVATOR | NFE2L2, KEAP1, NQO1 | SRD5A1 1473/4885BRD4 2509/4885TSHR 3246/4885 |
| US-10968181-B2 | NRF2 activator | NFE2L2, KEAP1, NQO1 | SRD5A1 1473/4885BRD4 2509/4885TSHR 3246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.