Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.67 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.58 |
| ▸ | MET | P08581 | 1/20 | 0.58 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.50 |
| ▸ | AXL | P30530 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 6/20 | 0.49 |
| ▸ | DRD2 | P14416 | 4/20 | 0.49 |
| ▸ | DRD3 | P35462 | 4/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31421790 | 0.84 | GPR84 (0.63) | GPR84LRRK2METMTNR1AAXL | |
| SCHEMBL6219244 | 0.81 | GPR84 (0.73) | GPR84LRRK2METMTNR1AAXL | |
| SCHEMBL27911675 | 0.80 | GPR84 (1.00) | GPR84LRRK2METMTNR1AAXL | |
| SCHEMBL2217980 | 0.79 | GPR84 (0.76) | GPR84LRRK2METMTNR1AAXL | |
| SCHEMBL7010590 | 0.77 | GPR84 (0.73) | GPR84LRRK2METMTNR1AAXL | |
| SCHEMBL2692513 | 0.77 | GPR84 (0.73) | GPR84LRRK2METMTNR1AAXL | |
| SCHEMBL7668337 | 0.77 | GPR84 (0.73) | GPR84LRRK2METMTNR1AAXL | |
| SCHEMBL31385845 | 0.77 | GPR84 (0.73) | GPR84LRRK2METMTNR1AAXL | |
| SCHEMBL1836680 | 0.77 | GPR84 (0.73) | GPR84LRRK2METMTNR1AAXL | |
| SCHEMBL3934105 | 0.77 | GPR84 (0.73) | GPR84LRRK2METMTNR1AAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12486264-B2 | Bicyclic HPK1 inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2025-12-02 | — | — | US | disclosed |
| US-20230002394-A1 | FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE | AKARNA THERAPEUTICS, LTD. (GB) | 2023-01-05 | — | — | US | disclosed |
| US-20220169644-A1 | BICYCLIC HPK1 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2022-06-02 | — | — | US | disclosed |
| EP-3177621-B1 | NOVEL HDAC6 INHIBITORS AND THEIR USES | UNIV REGENSBURG (DE) | 2021-11-10 | — | — | EP | disclosed |
| EP-3177621-B1 | NOVEL HDAC6 INHIBITORS AND THEIR USES | UNIV REGENSBURG (DE) | 2021-11-10 | — | — | EP | disclosed |
| US-20210214362-A1 | FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE | AKARNA THERAPEUTICS, LTD. (GB) | 2021-07-15 | — | — | US | disclosed |
| EP-3715348-A1 | FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE | Akarna Therapeutics, Ltd. (GB) | 2020-09-30 | — | — | EP | disclosed |
| US-10421759-B2 | Fused bicyclic compounds for the treatment of disease | AKARNA THERAPEUTICS, LTD. (GB) | 2019-09-24 | — | — | US | disclosed |
| WO-2018213422-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS (US) | 2018-11-22 | — | — | WO | disclosed |
| US-10106540-B2 | HDAC6 inhibitors and their uses | UNIVERSITÄT REGENSBURG (DE) | 2018-10-23 | — | — | US | disclosed |
| EP-0509974-B1 | Pyrrolo[2,3-b]pyridines having therapeutic activity and a process for the preparation thereof | ASTRA AB (SE) | 1999-01-13 | — | — | EP | disclosed |
| CN-1192202-A | Diheterocyclic acrylonitriles as smooth muscle cell proliferation inhibitors | AMERICAN HOME PROD (US) | 1998-09-02 | — | — | CN | disclosed |
| EP-0835244-A1 | DIHETEROCYCLIC ACRYLONITRILES AS SMOOTH MUSCLE CELL PROLIFERATION INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-04-15 | — | — | EP | disclosed |
| US-5710164-A | Diheterocyclic styryl nitriles | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-01-20 | — | — | US | disclosed |
| WO-1996039387-A1 | DIHETEROCYCLIC ACRYLONITRILES AS SMOOTH MUSCLE CELL PROLIFERATION INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-12-12 | — | — | WO | disclosed |
| US-5439917-A | Phenyl-pyrrolo(2,3-b)pyridine antisecretory agent of gastric acid; adenosine triphosphatase enzyme inhibitor | AKTIEBOLAGET ASTRA (SE) | 1995-08-08 | — | — | US | disclosed |
| WO-1995007910-A1 | ANTIVIRAL INDOLE DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-03-23 | — | — | WO | disclosed |
| EP-0580616-A1 | NEW ACTIVE COMPOUNDS | Astra Aktiebolag (SE) | 1994-02-02 | — | — | EP | disclosed |
| EP-0509974-A1 | Pyrrolo[2,3-b]pyridines having therapeutic activity and a process for the preparation thereof | Astra Aktiebolag (SE) | 1992-10-21 | — | — | EP | disclosed |
| WO-1992017477-A1 | NEW ACTIVE COMPOUNDS | AKTIEBOLAGET ASTRA (SE) | 1992-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10421759-B2 | Fused bicyclic compounds for the treatment of disease | VHL, BRDT, PAICS | GPR84 3671/4885LRRK2 3117/4885MET 1156/4885 |
| US-12486264-B2 | Bicyclic HPK1 inhibitors | PCK1, PGK1, PDXK | GPR84 2656/4885LRRK2 877/4885MET 1628/4885 |
| US-20220169644-A1 | BICYCLIC HPK1 INHIBITORS | PCK1, PGK1, PDXK | GPR84 2656/4885LRRK2 877/4885MET 1628/4885 |
| US-20230002394-A1 | FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE | VHL, BRDT, PAICS | GPR84 3671/4885LRRK2 3117/4885MET 1156/4885 |
| US-20210214362-A1 | FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE | VHL, BRDT, PAICS | GPR84 3671/4885LRRK2 3117/4885MET 1156/4885 |
| US-10106540-B2 | HDAC6 inhibitors and their uses | HDAC6, HDAC5, HDAC4 | GPR84 2704/4885LRRK2 1842/4885MET 661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.