Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | NAMPT | P43490 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MMP1 | P03956 | 3/20 | 0.49 |
| ▸ | MMP2 | P08253 | 3/20 | 0.49 |
| ▸ | MMP9 | P14780 | 3/20 | 0.49 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.49 |
| ▸ | P4HB | P07237 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20353523 | 0.88 | CYP3A4 (0.56) | CYP3A4MEN1KMT2ARAB9AMAPT | |
| SCHEMBL22857554 | 0.86 | ROCK2 (0.57) | CYP3A4KMT2ARAB9AALDH1A1LMNA | |
| SCHEMBL20353547 | 0.83 | BCHE (0.59) | CYP3A4MEN1KMT2ARAB9AMAPT | |
| SCHEMBL14124402 | 0.83 | IMPDH2 (0.64) | CYP3A4RAB9ANAMPTNPC1MMP1 | |
| SCHEMBL20353518 | 0.83 | MEN1 (0.70) | CYP3A4MEN1KMT2ARAB9AMAPT | |
| SCHEMBL20353520 | 0.83 | CYP3A4 (0.52) | CYP3A4MEN1KMT2ARAB9ACYP1A2 | |
| SCHEMBL22752027 | 0.82 | ROCK2 (0.57) | CYP3A4NAMPTIMPDH2 | |
| SCHEMBL27866511 | 0.81 | MEN1 (0.63) | CYP3A4MEN1KMT2ARAB9AMAPT | |
| SCHEMBL20353542 | 0.79 | CYP3A4 (0.58) | CYP3A4MEN1KMT2ARAB9AMAPT | |
| SCHEMBL22752111 | 0.78 | CYP3A4 (0.53) | CYP3A4MEN1KMT2ARAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10472327-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2019-11-12 | — | — | US | disclosed |
| US-20180186746-A1 | 6-AMINOISOQUINOLINE COMPOUNDS | ALCON INC. (CH) | 2018-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10472327-B2 | 6-aminoisoquinoline compounds | COQ8A, PGC, AGK | CYP3A4 2672/4885MEN1 3210/4885KMT2A 2030/4885 |
| US-20180186746-A1 | 6-AMINOISOQUINOLINE COMPOUNDS | COQ8A, PGC, AGK | CYP3A4 2672/4885MEN1 3210/4885KMT2A 2030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.