Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 5/20 | 0.63 |
| ▸ | PRMT3 | O60678 | 7/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.52 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28775933 | 0.90 | IMPDH2 (0.62) | IMPDH2PRMT3ROCK2ROCK1NOTUM | |
| SCHEMBL29771003 | 0.90 | IMPDH2 (0.62) | IMPDH2PRMT3ROCK2ROCK1NOTUM | |
| SCHEMBL20353582 | 0.88 | IMPDH2 (0.60) | IMPDH2PRMT3ROCK2ROCK1NOTUM | |
| SCHEMBL2864755 | 0.85 | IMPDH2 (0.61) | IMPDH2PRMT3ROCK2ROCK1NOTUM | |
| SCHEMBL2570139 | 0.83 | IMPDH2 (0.68) | IMPDH2PRMT3ROCK2ROCK1NOTUM | |
| SCHEMBL31514965 | 0.83 | IMPDH2 (0.68) | IMPDH2PRMT3ROCK2ROCK1NOTUM | |
| SCHEMBL30645380 | 0.83 | IMPDH2 (0.68) | IMPDH2PRMT3ROCK2ROCK1NOTUM | |
| SCHEMBL3557637 | 0.81 | PRMT3 (0.60) | IMPDH2PRMT3ROCK2NOTUMAAK1 | |
| SCHEMBL3557635 | 0.81 | IMPDH2 (0.59) | IMPDH2PRMT3ROCK2ROCK1NOTUM | |
| SCHEMBL30579695 | 0.81 | IMPDH2 (0.72) | IMPDH2PRMT3ROCK2ROCK1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10472327-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2019-11-12 | — | — | US | disclosed |
| US-20180186746-A1 | 6-AMINOISOQUINOLINE COMPOUNDS | ALCON INC. (CH) | 2018-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10472327-B2 | 6-aminoisoquinoline compounds | COQ8A, PGC, AGK | IMPDH2 2131/4885PRMT3 1026/4885ROCK2 246/4885 |
| US-20180186746-A1 | 6-AMINOISOQUINOLINE COMPOUNDS | COQ8A, PGC, AGK | IMPDH2 2131/4885PRMT3 1026/4885ROCK2 246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.