Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12495123 | 0.85 | ALDH1A1 (0.47) | ALDH1A1MAPTKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL12495120 | 0.85 | ALDH1A1 (0.47) | ALDH1A1MAPTKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL14222603 | 0.85 | DHODH (0.41) | ALDH1A1MAPTKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL4516541 | 0.83 | NAPRT (0.54) | ALDH1A1MAPTKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL25191564 | 0.81 | MAPT (0.47) | ALDH1A1MAPTKDM4ERAB9ANPSR1 | |
| SCHEMBL19329260 | 0.81 | MAOA (0.46) | ALDH1A1MAPTSMN1; SMN2NPC1NFKB1 | |
| SCHEMBL4272031 | 0.81 | DHODH (0.41) | ALDH1A1NPSR1EPHX1EPHX2DHODH | |
| SCHEMBL11022963 | 0.81 | NPC1 (0.44) | ALDH1A1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL30824201 | 0.81 | MDM2 (0.47) | ALDH1A1KDM4ESMN1; SMN2DHODHNAPRT | |
| SCHEMBL1733300 | 0.79 | SMN1; SMN2 (0.61) | ALDH1A1MAPTKDM4ESMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0684942-B1 | METHOD FOR PREPARING QUINOLINE CARBOXYLIC ACIDS AND DERIVATIVES THEREOF | HOECHST CELANESE CORP (US) | 1998-06-10 | — | — | EP | claimed |
| EP-0684942-A4 | — | — | 1995-12-27 | — | — | EP | claimed |
| EP-0684942-A1 | METHOD FOR PREPARING QUINOLINE CARBOXYLIC ACIDS AND DERIVATIVES THEREOF | HOECHST CELANESE CORPORATION (US) | 1995-12-06 | — | — | EP | claimed |
| US-5430152-A | Heating aminoarylester in presence of chlorosulfonic acid, oleum | HOECHST CELANESE CORPORATION (US) | 1995-07-04 | — | — | US | claimed |
| WO-1994019312-A1 | METHOD FOR PREPARING QUINOLINE CARBOXYLIC ACIDS AND DERIVATIVES THEREOF | HOECHST CELANESE CORPORATION (US) | 1994-09-01 | — | — | WO | claimed |
| US-4079058-A | Process of performing cyclization reactions using benzyl or pyridylamino malonic acid derivatives | DYNAMIT NOBEL AG (DT) | 1978-03-14 | — | — | US | claimed |
| JP-11158150-A | — | — | None | — | — | JP | disclosed |
| US-10894773-B2 | Deuterated CFTR potentiators | VERTEX PHARMACEUTICALS (EUROPE) LIMITED (GB) | 2021-01-19 | — | — | US | disclosed |
| US-20200290971-A1 | DEUTERATED CFTR POTENTIATORS | VERTEX PHARMACEUTICALS (EUROPE) LIMITED (GB) | 2020-09-17 | — | — | US | disclosed |
| US-10479766-B2 | Deuterated CFTR potentiators | Verex Pharmaceuticals (Europe) Limited (GB) | 2019-11-19 | — | — | US | disclosed |
| EP-3538512-A1 | NEW ANTHELMINTIC QUINOLINE-3-CARBOXAMIDE DERIVATIVES | Bayer Animal Health GmbH (DE) | 2019-09-18 | — | — | EP | disclosed |
| EP-3235812-B1 | DEUTERATED DERIVATIVES OF IVACAFTOR | VERTEX PHARMACEUTICALS EUROPE LTD (GB) | 2019-09-04 | — | — | EP | disclosed |
| US-20190169129-A1 | DEUTERATED CFTR POTENTIATORS | VERTEX PHARMACEUTICALS (EUROPE) LIMITED (GB) | 2019-06-06 | — | — | US | disclosed |
| US-4390541-A | ANTIALLERGENS; ANTISPASMODIC AGENTS | LILLY INDUSTRIES LIMITED (GB) | 1983-06-28 | — | — | US | disclosed |
| EP-0055068-A1 | Quinolone derivatives and their use as pharmaceuticals | Lilly Industries Limited (GB) | 1982-06-30 | — | — | EP | disclosed |
| EP-0022078-A1 | Pyrazolo-quinolines, processes for their production, and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1981-01-07 | — | — | EP | disclosed |
| US-4079058-A | Process of performing cyclization reactions using benzyl or pyridylamino malonic acid derivatives | DYNAMIT NOBEL AG (DT) | 1978-03-14 | — | — | US | disclosed |
| US-4079058-A | Process of performing cyclization reactions using benzyl or pyridylamino malonic acid derivatives | DYNAMIT NOBEL AG (DT) | 1978-03-14 | — | — | US | disclosed |
| US-3981717-A | ANILINO COMPOUNDS | AMERICAN CYANAMID COMPANY (US) | 1976-09-21 | — | — | US | disclosed |
| US-3907798-A | Preparation of 4H-pyrido{8 1,2-a{9 pyrimidin-4-ones from cyclic alkylidene 2-pyridylaminomethylenemalonates | STERLING DRUG INC | 1975-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190169129-A1 | DEUTERATED CFTR POTENTIATORS | CFTR, SLC26A3, SLC26A4 | ALDH1A1 1205/4885MAPT 4868/4885KDM4E 4762/4885 |
| US-20200290971-A1 | DEUTERATED CFTR POTENTIATORS | CFTR, SLC26A3, SLC26A4 | ALDH1A1 1205/4885MAPT 4868/4885KDM4E 4762/4885 |
| US-10479766-B2 | Deuterated CFTR potentiators | CFTR, SLC26A3, SLC26A4 | ALDH1A1 1205/4885MAPT 4868/4885KDM4E 4762/4885 |
| US-10894773-B2 | Deuterated CFTR potentiators | CFTR, SLC26A3, SLC26A4 | ALDH1A1 1205/4885MAPT 4868/4885KDM4E 4762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.