Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HCAR1 | Q9BXC0 | 4/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | DUT | P33316 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20356713 | 0.71 | PKM (0.42) | PKMCRBNDUT | |
| SCHEMBL23230384 | 0.62 | PKM (0.40) | PKM | |
| SCHEMBL24533108 | 0.62 | TSHR (0.46) | — | |
| SCHEMBL22887993 | 0.61 | PDE4B (0.30) | — | |
| SCHEMBL17371827 | 0.59 | PKM (1.00) | PKMCRBNDUT | |
| SCHEMBL25183491 | 0.58 | PKM (0.52) | PKMCRBNDUT | |
| SCHEMBL19942395 | 0.58 | PKM (0.36) | PKM | |
| SCHEMBL3723938 | 0.57 | APOBEC3A (0.40) | PKM | |
| SCHEMBL27663547 | 0.57 | PKM (0.50) | PKMCRBNDUT | |
| SCHEMBL26040211 | 0.56 | PKM (0.62) | PKMCRBNDUT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180186801-A1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2018-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180186801-A1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | PKM 2281/4885HCAR1 1115/4885CRBN 1773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.