Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | DUT | P33316 | 2/20 | 0.32 |
| ▸ | PLAT | P00750 | 2/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL404918 | 0.72 | PLAT (0.53) | PLAT | |
| SCHEMBL20356642 | 0.71 | PKM (0.42) | PKMCRBNDUT | |
| SCHEMBL18654699 | 0.69 | FLT3 (0.34) | — | |
| SCHEMBL14269847 | 0.69 | CRBN (0.38) | CRBNIRAK4 | |
| SCHEMBL23230384 | 0.68 | PKM (0.40) | PKM | |
| SCHEMBL405059 | 0.67 | PLAT (0.50) | PLATIRAK4 | |
| SCHEMBL31001803 | 0.66 | HCAR1 (0.36) | CRBNPLAT | |
| SCHEMBL10190930 | 0.66 | CRBN (0.34) | CRBNPLATIRAK4 | |
| SCHEMBL28948286 | 0.66 | PLAT (0.42) | CRBNPLATIRAK4 | |
| SCHEMBL406392 | 0.65 | PLAT (0.46) | PLATIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180186801-A1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2018-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180186801-A1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | PKM 2281/4885CRBN 1773/4885DUT 333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.