Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 6/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 2/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.33 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.33 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.33 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | PDE9A | O76083 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20373357 | 0.85 | NOX4 (0.43) | BRD4GRM4NOX4 | |
| SCHEMBL20373449 | 0.83 | SYK (0.38) | PDE5ATLR7NOX4SLC16A3SLC16A1 | |
| SCHEMBL20373361 | 0.83 | AVPR2 (0.34) | TLR7NOX4 | |
| SCHEMBL20373452 | 0.82 | KCNA5 (0.40) | PDE5ATLR7NOX4SLC16A3SLC16A1 | |
| SCHEMBL20373445 | 0.82 | TLR7 (0.33) | BRD4S1PR3TLR7NOX4PDE1B | |
| SCHEMBL20373284 | 0.81 | KDM4E (0.36) | TLR7NOX4PDE1B | |
| SCHEMBL20373360 | 0.81 | MET (0.40) | — | |
| SCHEMBL20373754 | 0.80 | TLR7 (0.37) | BRD4TLR7NOX4 | |
| SCHEMBL16906059 | 0.78 | BRD4 (0.51) | BRD4 | |
| SCHEMBL20373587 | 0.75 | BRD4 (0.37) | BRD4GRM4PDE5AS1PR3TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-07-11 | — | — | EP | disclosed |