Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.46 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.42 |
| ▸ | LSS | P48449 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20375636 | 0.90 | MGLL (0.46) | GPR119HSD11B1PIK3CDALDH1A1LMNA | |
| SCHEMBL12236474 | 0.86 | GPR119 (0.48) | GPR119HSD11B1MAPK7ADRB2PIK3CD | |
| SCHEMBL12236417 | 0.84 | GPR119 (0.51) | GPR119HSD11B1MAPK7CYP2C9 | |
| SCHEMBL20375627 | 0.80 | RBP4 (0.55) | GPR119PIK3CDL3MBTL1 | |
| SCHEMBL20375645 | 0.79 | GPR119 (0.55) | GPR119PIK3CDCYP2C9 | |
| SCHEMBL20375405 | 0.78 | GPR119 (0.56) | GPR119PIK3CD | |
| SCHEMBL12236539 | 0.76 | GPR119 (0.49) | GPR119MAPK7PIK3CDCYP2C9MEN1 | |
| SCHEMBL12236481 | 0.76 | MGLL (0.46) | GPR119PIK3CDPOLBMEN1KMT2A | |
| SCHEMBL12236480 | 0.76 | MAPK7 (0.48) | GPR119HSD11B1MAPK7ADRB2PIK3CD | |
| SCHEMBL3810600 | 0.76 | GPR119 (0.44) | GPR119CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382204-B1 | PYRIMIDINE DERIVATIVES AS GPCR MODULATORS FOR USE IN THE TREATMENT OF OBESITY AND DIABETES | MERCK SHARP & DOHME (US) | 2018-07-11 | — | — | EP | disclosed |