Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 1/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12236475 | 0.87 | RBP4 (0.56) | RBP4PIK3CDGPR119L3MBTL1EPHX2 | |
| SCHEMBL12236420 | 0.85 | RBP4 (0.54) | RBP4PIK3CDGPR119L3MBTL1 | |
| SCHEMBL20375636 | 0.80 | MGLL (0.46) | PIK3CDGPR119 | |
| SCHEMBL20375412 | 0.80 | GPR119 (0.46) | PIK3CDGPR119L3MBTL1 | |
| SCHEMBL20375645 | 0.78 | GPR119 (0.55) | PIK3CDGPR119 | |
| SCHEMBL20375405 | 0.77 | GPR119 (0.56) | PIK3CDGPR119 | |
| SCHEMBL3811986 | 0.75 | GPR119 (0.47) | RBP4PIK3CDGPR119EPHX2 | |
| SCHEMBL3811989 | 0.75 | GPR119 (0.47) | RBP4PIK3CDGPR119EPHX2 | |
| SCHEMBL3811526 | 0.74 | GPR119 (0.46) | RBP4PIK3CDGPR119 | |
| SCHEMBL3811530 | 0.74 | GPR119 (0.46) | RBP4PIK3CDGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382204-B1 | PYRIMIDINE DERIVATIVES AS GPCR MODULATORS FOR USE IN THE TREATMENT OF OBESITY AND DIABETES | MERCK SHARP & DOHME (US) | 2018-07-11 | — | — | EP | disclosed |